SSBD:database

Key Organism Strain Cell Line Gene Symbol Protein name Protein tag Reporter Project ID Dataset ID Title Description Data Type Gene Ontology Biological Imaging Methods Method Summary Paper Information Medical Subject Headlines Person

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535-Ohashi-AxolotlSkinDCF

https://ssbd.riken.jp/database/535-Ohashi-AxolotlSkinDCF/

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ssbd-repos-000535

https://ssbd.riken.jp/repository/535/

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Z-stack images showing keratinocyte-driven dermal collagen formation in the axolotl skin

Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We reveal the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarify that epidermal cells, not dermal fibroblasts, contribute to dermal collagen formation. Mesenchymal cells (fibroblasts) play a role in modifying the collagen fibers already built by keratinocytes. We confirm that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings warrant a change in the current consensus about dermal collagen formation and could lead to innovations in cosmetology and skin medication.

2026-10-01

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CC BY 4.0

Image data based on Experiment

7 ( Image datasets: 7, Quantitative data datasets: 0 )

1.4 GB ( Image datasets: 1.4 GB, Quantitative data datasets: 0 bytes )

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Ambystoma mexicanum

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extracellular matrix organization collagen metabolic process collagen fibril organization collagen biosynthetic process, extracellular matrix organization collagen metabolic process collagen fibril organization, extracellular matrix organization collagen metabolic process mesenchymal cell migration

extracellular matrix, extracellular matrix cytoplasm, extracellular matrix fibrillar collagen complex

confocal microscopy

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Akira Satoh , Okayama University , Faculty of Environmental, Life, Natural Science and Technology , Faculty of Environmental, Life, Natural Science and Technology

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