SSBD:database

Thumbnail for 289-Fujimoto-MitralCell

Summary of 289-Fujimoto-MitralCell

SSBD:database
289-Fujimoto-MitralCell
SSBD:database URL
https://ssbd.riken.jp/database/289-Fujimoto-MitralCell/
SSBD:repository
ssbd-repos-000289
SSBD:repository URL
https://ssbd.riken.jp/repository/289/
Title
Image data showing activity-dependent dendrite remodeling in the developing mouse olfactory bulb and barrel cortex
Description
In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; however, it has remained unknown how different synapses compete with one another within a post-synaptic cell. Here, the authors investigate how a mitral cell in the mouse olfactory bulb prunes all but one primary dendrite during the developmental remodeling process. They find that spontaneous activity generated within the olfactory bulb is essential. They show that strong glutamatergic inputs to one dendrite trigger branch-specific changes in RhoA activity to facilitate the pruning of the remaining dendrites: NMDAR-dependent local signals suppress RhoA to protect it from pruning; however, the subsequent neuronal depolarization induces neuron-wide activation of RhoA to prune non-protected dendrites. NMDAR-RhoA signals are also essential for the synaptic competition in the mouse barrel cortex. These results demonstrate a general principle whereby activity-dependent lateral inhibition across synapses establishes a discrete receptive field of a neuron.
Release date
2026-08-07
Updated date
-
License
CC BY 4.0
Kind
Image data based on Experiment
Number of Datasets
461 ( Image datasets: 461, Quantitative data datasets: 0 )
Size of Datasets
751.2 GB ( Image datasets: 751.2 GB, Quantitative data datasets: 0 bytes )
Organism(s)
Mus musculus
Strain(s)
C57BL/6N, ICR
Datatype
-
Molecular Function (MF)
Biological Process (BP)
neuron development, neuron development neuron remodeling, postsynaptic signal transduction, calcium ion transport, negative regulation of neuron remodeling, calcium ion transport response to odorant
Cellular Component (CC)
dendrite glutamatergic synapse, cell body dendrite, cytoplasm presynapse, dendrite, axon
Biological Imaging Method
two-photon laser scanning microscopy, confocal microscopy
T scale
0.564 seconds 0.842 seconds 0.429 seconds 0.429 seconds, 0.151 seconds, 0.032 seconds, 0.429 seconds 0.429 seconds 0.429 seconds 0.429 seconds, 10 seconds, 0.564 seconds 0.564 seconds 0.564 seconds, 0.429 seconds 0.429 seconds 0.429 seconds, 0.429 seconds 0.429 seconds, 0.375 seconds 0.397 seconds, 0.429 seconds 0.429 seconds 0.429 seconds 0.429 seconds 0.429 seconds 0.564 seconds, 0.564 seconds, 0.4 seconds, 0.429 seconds, 5 seconds, NA, 0.035 seconds, 0.43 seconds
Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Related paper(s)
Contact
Takeshi Imai, , Kyushu University, , Graduate School of Medical Sciences, , Graduate School of Medical Sciences,
Contributors

Dataset List of 289-Fujimoto-MitralCell

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#
Dataset ID
Kind
Size
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Thumbnail Thumbnail for dataset Fig1B_P1
# 16975
Datast ID Fig1B_P1
Dataset Kind Image data
Dataset Size 115.5 MB
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Thumbnail Thumbnail for dataset Fig1B_P3
# 16976
Datast ID Fig1B_P3
Dataset Kind Image data
Dataset Size 108.0 MB
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Thumbnail Thumbnail for dataset Fig1B_P6
# 16977
Datast ID Fig1B_P6
Dataset Kind Image data
Dataset Size 85.9 MB
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Thumbnail Thumbnail for dataset Fig1E_P1
# 16978
Datast ID Fig1E_P1
Dataset Kind Image data
Dataset Size 1.1 GB
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Thumbnail Thumbnail for dataset Fig1E_P3
# 16979
Datast ID Fig1E_P3
Dataset Kind Image data
Dataset Size 2.9 GB
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Thumbnail Thumbnail for dataset Fig1E_P6
# 16980
Datast ID Fig1E_P6
Dataset Kind Image data
Dataset Size 2.5 GB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1G_P3_ctrl
# 16981
Datast ID Fig1G_P3_ctrl
Dataset Kind Image data
Dataset Size 27.0 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1G_P6_ctrl
# 16982
Datast ID Fig1G_P6_ctrl
Dataset Kind Image data
Dataset Size 28.6 MB
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Thumbnail Thumbnail for dataset Fig1G_P10_ctrl
# 16983
Datast ID Fig1G_P10_ctrl
Dataset Kind Image data
Dataset Size 17.3 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1G_P14_ctrl
# 16984
Datast ID Fig1G_P14_ctrl
Dataset Kind Image data
Dataset Size 37.7 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1G_P3_Kir
# 16985
Datast ID Fig1G_P3_Kir
Dataset Kind Image data
Dataset Size 31.1 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1G_P6_Kir
# 16986
Datast ID Fig1G_P6_Kir
Dataset Kind Image data
Dataset Size 27.3 MB
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Thumbnail Thumbnail for dataset Fig1G_P10_Kir
# 16987
Datast ID Fig1G_P10_Kir
Dataset Kind Image data
Dataset Size 28.9 MB
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Thumbnail Thumbnail for dataset Fig1G_P14_Kir
# 16988
Datast ID Fig1G_P14_Kir
Dataset Kind Image data
Dataset Size 33.8 MB
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Thumbnail Thumbnail for dataset Fig1HI_P3_ctrl_1
# 16989
Datast ID Fig1HI_P3_ctrl_1
Dataset Kind Image data
Dataset Size 966.6 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P3_ctrl_2
# 16990
Datast ID Fig1HI_P3_ctrl_2
Dataset Kind Image data
Dataset Size 606.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P3_ctrl_3
# 16991
Datast ID Fig1HI_P3_ctrl_3
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P3_Kir_1
# 16992
Datast ID Fig1HI_P3_Kir_1
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P3_Kir_2
# 16993
Datast ID Fig1HI_P3_Kir_2
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P3_Kir_3
# 16994
Datast ID Fig1HI_P3_Kir_3
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P6_ctrl_1
# 16995
Datast ID Fig1HI_P6_ctrl_1
Dataset Kind Image data
Dataset Size 942.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P6_ctrl_2
# 16996
Datast ID Fig1HI_P6_ctrl_2
Dataset Kind Image data
Dataset Size 726.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P6_ctrl_3
# 16997
Datast ID Fig1HI_P6_ctrl_3
Dataset Kind Image data
Dataset Size 726.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P6_Kir_1
# 16998
Datast ID Fig1HI_P6_Kir_1
Dataset Kind Image data
Dataset Size 786.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P6_Kir_2
# 16999
Datast ID Fig1HI_P6_Kir_2
Dataset Kind Image data
Dataset Size 846.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P6_Kir_3
# 17000
Datast ID Fig1HI_P6_Kir_3
Dataset Kind Image data
Dataset Size 786.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P10_ctrl_1
# 17001
Datast ID Fig1HI_P10_ctrl_1
Dataset Kind Image data
Dataset Size 906.6 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P10_ctrl_2
# 17002
Datast ID Fig1HI_P10_ctrl_2
Dataset Kind Image data
Dataset Size 786.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P10_ctrl_3
# 17003
Datast ID Fig1HI_P10_ctrl_3
Dataset Kind Image data
Dataset Size 607.9 MB
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Thumbnail Thumbnail for dataset Fig1HI_P10_Kir_1
# 17004
Datast ID Fig1HI_P10_Kir_1
Dataset Kind Image data
Dataset Size 906.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P10_Kir_2
# 17005
Datast ID Fig1HI_P10_Kir_2
Dataset Kind Image data
Dataset Size 1.0 GB
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Thumbnail Thumbnail for dataset Fig1HI_P10_Kir_3
# 17006
Datast ID Fig1HI_P10_Kir_3
Dataset Kind Image data
Dataset Size 1.0 GB
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Thumbnail Thumbnail for dataset Fig1HI_P10_Kir_4
# 17007
Datast ID Fig1HI_P10_Kir_4
Dataset Kind Image data
Dataset Size 607.8 MB
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Thumbnail Thumbnail for dataset Fig1HI_P14_ctrl_1
# 17008
Datast ID Fig1HI_P14_ctrl_1
Dataset Kind Image data
Dataset Size 786.6 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P14_ctrl_2
# 17009
Datast ID Fig1HI_P14_ctrl_2
Dataset Kind Image data
Dataset Size 786.6 MB
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Thumbnail Thumbnail for dataset Fig1HI_P14_ctrl_3
# 17010
Datast ID Fig1HI_P14_ctrl_3
Dataset Kind Image data
Dataset Size 1.3 GB
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Thumbnail Thumbnail for dataset Fig1HI_P14_Kir_1
# 17011
Datast ID Fig1HI_P14_Kir_1
Dataset Kind Image data
Dataset Size 606.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P14_Kir_2
# 17012
Datast ID Fig1HI_P14_Kir_2
Dataset Kind Image data
Dataset Size 607.9 MB
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Thumbnail Thumbnail for dataset Fig1HI_P14_Kir_3
# 17013
Datast ID Fig1HI_P14_Kir_3
Dataset Kind Image data
Dataset Size 607.9 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P28_ctrl_1
# 17014
Datast ID Fig1HI_P28_ctrl_1
Dataset Kind Image data
Dataset Size 1.0 GB
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Thumbnail Thumbnail for dataset Fig1HI_P28_ctrl_2
# 17015
Datast ID Fig1HI_P28_ctrl_2
Dataset Kind Image data
Dataset Size 786.5 MB
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Thumbnail Thumbnail for dataset Fig1HI_P28_ctrl_3
# 17016
Datast ID Fig1HI_P28_ctrl_3
Dataset Kind Image data
Dataset Size 607.8 MB
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Thumbnail Thumbnail for dataset Fig1HI_P28_Kir_1
# 17017
Datast ID Fig1HI_P28_Kir_1
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P28_Kir_2
# 17018
Datast ID Fig1HI_P28_Kir_2
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P28_Kir_3
# 17019
Datast ID Fig1HI_P28_Kir_3
Dataset Kind Image data
Dataset Size 606.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1HI_P28_Kir_4
# 17020
Datast ID Fig1HI_P28_Kir_4
Dataset Kind Image data
Dataset Size 607.9 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1L_P6_ctrl_1
# 17021
Datast ID Fig1L_P6_ctrl_1
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1L_P6_ctrl_2
# 17022
Datast ID Fig1L_P6_ctrl_2
Dataset Kind Image data
Dataset Size 786.5 MB
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SSBD:OMERO
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Thumbnail Thumbnail for dataset Fig1L_P6_ctrl_3
# 17023
Datast ID Fig1L_P6_ctrl_3
Dataset Kind Image data
Dataset Size 606.5 MB
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Thumbnail Thumbnail for dataset Fig1L_P6_OSN-TeNT_1
# 17024
Datast ID Fig1L_P6_OSN-TeNT_1
Dataset Kind Image data
Dataset Size 786.5 MB
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