Summary of 139-Kishimoto-TracheaDev

SSBD:database
SSBD:database URL
Title
Image data of trachea and esophagus formation in the mouse embryo
Description
-
Relase date
2024-11-25
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
85 ( Image datasets: 85, Quantitative data datasets: 0 )
Size of Datasets
5.3 GB ( Image datasets: 5.3 GB, Quantitative data datasets: 0 bytes )

Organism(s)
Mus musculus
Gene symbol(s)
NA
Protein name(s)
NA

Datatype
-
Molecular Function (MF)
Biological Process (BP)
branching morphogenesis of an epithelial tube
Cellular Component (CC)
nucleus, cytoskeleton
Biological Imaging Method
time lapse microscopy, scanning electron microscopy, confocal microscopy, multi-photon microscopy
T scale
1 hour per time interval, NA

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Keishi Kishimoto, Masaru Tamura, Michiru Nishita, Yasuhiro Minami, Akira Yamaoka, Takaya Abe, Mayo Shigeta, Mitsuru Morimoto (2018) Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus., Nature communications, Volume 9, Number 1, pp. 2816

Published in 2018 Jul 19 (Electronic publication in July 19, 2018, midnight )

(Abstract) Tube morphogenesis is essential for internal-organ development, yet the mechanisms regulating tube shape remain unknown. Here, we show that different mechanisms regulate the length and diameter of the murine trachea. First, we found that trachea development progresses via sequential elongation and expansion processes. This starts with a synchronized radial polarization of smooth muscle (SM) progenitor cells with inward Golgi-apparatus displacement regulates tube elongation, controlled by mesenchymal Wnt5a-Ror2 signaling. This radial polarization directs SM progenitor cell migration toward the epithelium, and the resulting subepithelial morphogenesis supports tube elongation to the anteroposterior axis. This radial polarization also regulates esophageal elongation. Subsequently, cartilage development helps expand the tube diameter, which drives epithelial-cell reshaping to determine the optimal lumen shape for efficient respiration. These findings suggest a strategy in which straight-organ tubulogenesis is driven by subepithelial cell polarization and ring cartilage development.
(MeSH Terms)

Contact
Mitsuru Morimoto , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Lung Development
Contributors


Dataset List of 139-Kishimoto-TracheaDev

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
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# 11593
Dataset Kind Image data
Dataset Size 237.1 KB
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SSBD:OMERO
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# 11594
Dataset Kind Image data
Dataset Size 227.0 KB
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SSBD:OMERO
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# 11595
Dataset Kind Image data
Dataset Size 541.2 KB
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SSBD:OMERO
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# 11596
Dataset Kind Image data
Dataset Size 600.8 KB
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# 11597
Dataset Kind Image data
Dataset Size 391.3 KB
4D view
SSBD:OMERO
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# 11598
Dataset Kind Image data
Dataset Size 323.0 KB
4D view
SSBD:OMERO
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# 11599
Dataset Kind Image data
Dataset Size 292.1 KB
4D view
SSBD:OMERO
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# 11600
Dataset Kind Image data
Dataset Size 236.5 KB
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SSBD:OMERO
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# 11601
Dataset Kind Image data
Dataset Size 245.7 KB
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SSBD:OMERO
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# 11602
Dataset Kind Image data
Dataset Size 55.0 KB
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SSBD:OMERO
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# 11603
Dataset Kind Image data
Dataset Size 82.7 KB
4D view
SSBD:OMERO
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# 11604
Datast ID Figure3A_E10.5_KO
Dataset Kind Image data
Dataset Size 728.1 KB
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SSBD:OMERO
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# 11605
Datast ID Figure3A_E10.5_WT
Dataset Kind Image data
Dataset Size 728.1 KB
4D view
SSBD:OMERO
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# 11606
Datast ID Figure3A_E11.5_KO
Dataset Kind Image data
Dataset Size 802.8 KB
4D view
SSBD:OMERO
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# 11607
Datast ID Figure3A_E11.5_WT
Dataset Kind Image data
Dataset Size 802.8 KB
4D view
SSBD:OMERO
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# 11608
Datast ID Figure3A_E12.5_KO
Dataset Kind Image data
Dataset Size 1.6 MB
4D view
SSBD:OMERO
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# 11609
Datast ID Figure3A_E12.5_WT
Dataset Kind Image data
Dataset Size 1.6 MB
4D view
SSBD:OMERO
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# 11610
Datast ID Figure3A_E18.5_KO
Dataset Kind Image data
Dataset Size 298.2 KB
4D view
SSBD:OMERO
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# 11611
Datast ID Figure3A_E18.5_WT
Dataset Kind Image data
Dataset Size 298.2 KB
4D view
SSBD:OMERO
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# 11612
Datast ID Figure4H_Wnt5a_KO
Dataset Kind Image data
Dataset Size 600.8 MB
4D view
SSBD:OMERO
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# 11613
Datast ID Figure4H_Wnt5a_WT
Dataset Kind Image data
Dataset Size 600.8 MB
4D view
SSBD:OMERO
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# 11614
Dataset Kind Image data
Dataset Size 760.3 MB
4D view
SSBD:OMERO
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# 11615
Dataset Kind Image data
Dataset Size 892.3 MB
4D view
SSBD:OMERO
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# 11616
Dataset Kind Image data
Dataset Size 384.2 MB
4D view
SSBD:OMERO
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# 11617
Dataset Kind Image data
Dataset Size 568.2 MB
4D view
SSBD:OMERO
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# 11618
Dataset Kind Image data
Dataset Size 1.1 GB
4D view
SSBD:OMERO
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# 11619
Dataset Kind Image data
Dataset Size 376.2 MB
4D view
SSBD:OMERO
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# 11620
Dataset Kind Image data
Dataset Size 157.4 KB
4D view
SSBD:OMERO
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# 11621
Dataset Kind Image data
Dataset Size 324.2 KB
4D view
SSBD:OMERO
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# 11622
Dataset Kind Image data
Dataset Size 480.9 KB
4D view
SSBD:OMERO
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# 11623
Dataset Kind Image data
Dataset Size 614.4 KB
4D view
SSBD:OMERO
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# 11624
Datast ID FigureS1A_Brdu_P10
Dataset Kind Image data
Dataset Size 1.4 MB
4D view
SSBD:OMERO
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# 11625
Dataset Kind Image data
Dataset Size 4.5 MB
4D view
SSBD:OMERO
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# 11626
Dataset Kind Image data
Dataset Size 5.1 MB
4D view
SSBD:OMERO
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# 11627
Dataset Kind Image data
Dataset Size 8.0 MB
4D view
SSBD:OMERO
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# 11628
Dataset Kind Image data
Dataset Size 12.5 MB
4D view
SSBD:OMERO
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# 11629
Dataset Kind Image data
Dataset Size 9.6 MB
4D view
SSBD:OMERO
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# 11630
Dataset Kind Image data
Dataset Size 14.2 MB
4D view
SSBD:OMERO
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# 11631
Dataset Kind Image data
Dataset Size 20.3 MB
4D view
SSBD:OMERO
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# 11632
Dataset Kind Image data
Dataset Size 15.3 MB
4D view
SSBD:OMERO
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# 11633
Dataset Kind Image data
Dataset Size 496.8 KB
4D view
SSBD:OMERO
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# 11634
Dataset Kind Image data
Dataset Size 522.6 KB
4D view
SSBD:OMERO
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# 11635
Dataset Kind Image data
Dataset Size 144.2 KB
4D view
SSBD:OMERO
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# 11636
Dataset Kind Image data
Dataset Size 120.2 KB
4D view
SSBD:OMERO
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# 11637
Dataset Kind Image data
Dataset Size 220.1 KB
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# 11638
Dataset Kind Image data
Dataset Size 213.9 KB
4D view
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# 11639
Dataset Kind Image data
Dataset Size 371.7 KB
4D view
SSBD:OMERO
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# 11640
Dataset Kind Image data
Dataset Size 365.6 KB
4D view
SSBD:OMERO
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# 11641
Dataset Kind Image data
Dataset Size 454.3 KB
4D view
SSBD:OMERO
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# 11642
Dataset Kind Image data
Dataset Size 448.2 KB
4D view
SSBD:OMERO
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# 11643
Dataset Kind Image data
Dataset Size 126.2 KB
4D view
SSBD:OMERO
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# 11644
Dataset Kind Image data
Dataset Size 120.2 KB
4D view
SSBD:OMERO
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# 11645
Dataset Kind Image data
Dataset Size 220.0 KB
4D view
SSBD:OMERO
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# 11646
Dataset Kind Image data
Dataset Size 213.9 KB
4D view
SSBD:OMERO
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# 11647
Dataset Kind Image data
Dataset Size 371.7 KB
4D view
SSBD:OMERO
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# 11648
Dataset Kind Image data
Dataset Size 365.7 KB
4D view
SSBD:OMERO
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# 11649
Dataset Kind Image data
Dataset Size 317.9 KB
4D view
SSBD:OMERO
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# 11650
Dataset Kind Image data
Dataset Size 311.9 KB
4D view
SSBD:OMERO
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# 11651
Dataset Kind Image data
Dataset Size 642.9 KB
4D view
SSBD:OMERO
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# 11652
Dataset Kind Image data
Dataset Size 722.4 KB
4D view
SSBD:OMERO
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# 11653
Dataset Kind Image data
Dataset Size 585.1 KB
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SSBD:OMERO
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# 11654
Dataset Kind Image data
Dataset Size 47.7 KB
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SSBD:OMERO
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# 11655
Dataset Kind Image data
Dataset Size 47.7 KB
4D view
SSBD:OMERO
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# 11656
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11657
Dataset Kind Image data
Dataset Size 41.6 KB
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SSBD:OMERO
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# 11658
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11659
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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# 11660
Dataset Kind Image data
Dataset Size 41.6 KB
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SSBD:OMERO
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# 11661
Dataset Kind Image data
Dataset Size 41.6 KB
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SSBD:OMERO
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# 11662
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11663
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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# 11664
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11665
Dataset Kind Image data
Dataset Size 41.6 KB
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SSBD:OMERO
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# 11666
Dataset Kind Image data
Dataset Size 47.7 KB
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SSBD:OMERO
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# 11667
Dataset Kind Image data
Dataset Size 192.3 KB
4D view
SSBD:OMERO
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# 11668
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11669
Dataset Kind Image data
Dataset Size 41.7 KB
4D view
SSBD:OMERO
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# 11670
Dataset Kind Image data
Dataset Size 41.6 KB
4D view
SSBD:OMERO
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# 11671
Dataset Kind Image data
Dataset Size 192.3 KB
4D view
SSBD:OMERO
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# 11672
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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# 11673
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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# 11674
Dataset Kind Image data
Dataset Size 24.6 KB
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SSBD:OMERO
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# 11675
Dataset Kind Image data
Dataset Size 192.3 KB
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SSBD:OMERO
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# 11676
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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# 11677
Dataset Kind Image data
Dataset Size 41.7 KB
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SSBD:OMERO
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