Summary of 479-Ikebe-MorphResDL
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Title
The morphology of some kinds of Escherichia coli resistant to various antibiotics
Description
Although it is well known that the morphology of Gram-negative rods changes on exposure to antibiotics, the morphology of antibiotic-resistant bacteria in the absence of antibiotics has not been widely investigated. Here, we studied the morphologies of 10 antibiotic-resistant strains of Escherichia coli and used bioinformatics tools to classify the resistant cells under light microscopy in the absence of antibiotics. The antibiotic-resistant strains showed differences in morphology from the sensitive parental strain, and the differences were most prominent in the quinolone-and β-lactam-resistant bacteria. A cluster analysis revealed increased proportions of fatter or shorter cells in the antibiotic-resistant strains. A correlation analysis of morphological features and gene expression suggested that genes related to energy metabolism and antibiotic resistance were highly correlated with the morphological characteristics of the resistant strains. Our newly proposed deep learning method for single-cell classification achieved a high level of performance in classifying quinolone-and β-lactam-resistant strains.
Release date
2026-07-08
Updated date
-
License
CC BY 4.0
Kind
Image data
based on Experiment
Number of Datasets
2991
( Image datasets: 2991,
Quantitative data datasets: 0 )
Size of Datasets
84.2 GB
( Image datasets: 84.2 GB,
Quantitative data datasets: 0 bytes )
Organism(s)
Escherichia coli
Strain(s)
Escherichia coli str. K-12 substr. MDS42
Datatype
-
Molecular Function (MF)
Biological Process (BP)
cell growth, response to antibiotic regulation of cell shape cell growth
Cellular Component (CC)
cell envelope cell wall
Biological Imaging Method
phase contrast microscopy
T scale
-
Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Related paper(s)
Contact
Kota Aoki, Mitsuko Hayashi-Nishino, Kunihiko Nishino
, Osaka University, Osaka University, Osaka University
, SANKEN (Institute of Scientific and Industrial Research), SANKEN (Institute of Scientific and Industrial Research), SANKEN (Institute of Scientific and Industrial Research)
, SANKEN (Institute of Scientific and Industrial Research), SANKEN (Institute of Scientific and Industrial Research), SANKEN (Institute of Scientific and Industrial Research)
Contributors
Dataset List of 479-Ikebe-MorphResDL
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#
13965
Datast ID
AMK_20220511_AMK1_0001
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13966
Datast ID
AMK_20220511_AMK1_0002
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13967
Datast ID
AMK_20220511_AMK1_0003
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13968
Datast ID
AMK_20220511_AMK1_0004
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13969
Datast ID
AMK_20220511_AMK1_0005
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13970
Datast ID
AMK_20220511_AMK1_0006
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13971
Datast ID
AMK_20220511_AMK1_0007
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13972
Datast ID
AMK_20220511_AMK1_0008
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13973
Datast ID
AMK_20220511_AMK1_0009
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13974
Datast ID
AMK_20220511_AMK1_0010
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13975
Datast ID
AMK_20220511_AMK1_0011
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13976
Datast ID
AMK_20220511_AMK1_0012
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13977
Datast ID
AMK_20220511_AMK1_0013
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13978
Datast ID
AMK_20220511_AMK1_0014
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13979
Datast ID
AMK_20220511_AMK1_0015
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13980
Datast ID
AMK_20220511_AMK1_0016
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13981
Datast ID
AMK_20220511_AMK1_0017
Dataset Kind
Image data
Dataset Size
28.8 MB
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Thumbnail
#
13982
Datast ID
AMK_20220511_AMK1_0018
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13983
Datast ID
AMK_20220511_AMK1_0019
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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Thumbnail
#
13984
Datast ID
AMK_20220511_AMK1_0020
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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Thumbnail
#
13985
Datast ID
AMK_20220511_AMK2_0001
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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Thumbnail
#
13986
Datast ID
AMK_20220511_AMK2_0002
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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Thumbnail
#
13987
Datast ID
AMK_20220511_AMK2_0003
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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#
13988
Datast ID
AMK_20220511_AMK2_0004
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13989
Datast ID
AMK_20220511_AMK2_0005
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13990
Datast ID
AMK_20220511_AMK2_0006
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13991
Datast ID
AMK_20220511_AMK2_0007
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13992
Datast ID
AMK_20220511_AMK2_0008
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13993
Datast ID
AMK_20220511_AMK2_0009
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13994
Datast ID
AMK_20220511_AMK2_0010
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13995
Datast ID
AMK_20220511_AMK2_0011
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13996
Datast ID
AMK_20220511_AMK2_0012
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13997
Datast ID
AMK_20220511_AMK2_0013
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13998
Datast ID
AMK_20220511_AMK2_0014
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
13999
Datast ID
AMK_20220511_AMK2_0015
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14000
Datast ID
AMK_20220511_AMK2_0016
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14001
Datast ID
AMK_20220511_AMK2_0017
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14002
Datast ID
AMK_20220511_AMK2_0018
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14003
Datast ID
AMK_20220511_AMK2_0019
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14004
Datast ID
AMK_20220511_AMK2_0020
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14005
Datast ID
AMK_20220511_AMK3_0001
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14006
Datast ID
AMK_20220511_AMK3_0002
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14007
Datast ID
AMK_20220511_AMK3_0003
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14008
Datast ID
AMK_20220511_AMK3_0004
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14009
Datast ID
AMK_20220511_AMK3_0005
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14010
Datast ID
AMK_20220511_AMK3_0006
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14011
Datast ID
AMK_20220511_AMK3_0007
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14012
Datast ID
AMK_20220511_AMK3_0008
Dataset Kind
Image data
Dataset Size
28.8 MB
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#
14013
Datast ID
AMK_20220511_AMK3_0009
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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#
14014
Datast ID
AMK_20220511_AMK3_0010
Dataset Kind
Image data
Dataset Size
28.8 MB
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SSBD:OMERO
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