SSBD:database

Summary of 135-Maruyama-LymVesselImmuno

Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Kaoru Mizukami, Fumio Matsuzaki, Hiroki Kurihara (2019) Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development., Developmental biology, Volume 452, Number 2, pp. 134-143

Published in 2019 Aug 15 (Electronic publication in May 18, 2019, midnight )

• doi: 10.1016/j.ydbio.2019.05.002
• pmid: 31112709
  

(Abstract) The origin of the mammalian lymphatic vasculature has been studied for more than a century; however, details regarding organ-specific lymphatic development remain unknown. A recent study reported that cardiac lymphatic endothelial cells (LECs) stem from venous and non-venous origins in mice. Here, we identified Isl1-expressing progenitors as a potential non-venous origin of cardiac LECs. Genetic lineage tracing with Isl1-Cre reporter mice suggested a possible contribution from the Isl1-expressing pharyngeal mesoderm constituting the second heart field to lymphatic vessels around the cardiac outflow tract as well as to those in the facial skin and the lymph sac. Isl1(+) lineage-specific deletion of Prox1 resulted in disrupted LYVE1(+) vessel structures, indicating a Prox1-dependent mechanism in this contribution. Tracing back to earlier embryonic stages revealed the presence of VEGFR3(+) and/or Prox1(+) cells that overlapped with the Isl1(+) pharyngeal core mesoderm. These data may provide insights into the developmental basis of heart diseases involving lymphatic vasculature and improve our understanding of organ-based lymphangiogenesis.

• Animals
• Cell Lineage[major]
• Endothelial Cells/metabolism
• Heart/embryology[major]
• Homeodomain Proteins/metabolism
• LIM-Homeodomain Proteins/metabolism[major]
• Lymphangiogenesis[major]
• Lymphatic Vessels/cytology[major]
• Lymphatic Vessels/embryology[major]
• Mesoderm/embryology
• Mesoderm/metabolism
• Mice
• Pharynx/cytology
• Stem Cells/metabolism
• Transcription Factors/metabolism[major]
• Tumor Suppressor Proteins/metabolism
• Vascular Endothelial Growth Factor Receptor-3/metabolism