Summary of 15-Harima-GeneExp

SSBD:database
SSBD:database URL
Title
-
Description
-
Relase date
2016-01-18
Updated date
2018-11-15
License
CC BY-NC-SA
Kind
Quantitative data, Image data based on Experiment
Number of Datasets
4 ( Image datasets: 2, Quantitative data datasets: 2 )
Size of Datasets
1.0 MB ( Image datasets: 398.1 KB, Quantitative data datasets: 649.4 KB )

Organism(s)
M. musculus
Gene symbol(s)
Hes7
Protein name(s)
NA

Datatype
gene expression data
Molecular Function (MF)
Biological Process (BP)
-
Cellular Component (CC)
-
Biological Imaging Method
-
XYZ Scale
-
T scale
5 minute for each time interval

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Yukiko Harima, Yoshiki Takashima, Yuriko Ueda, Toshiyuki Ohtsuka, Ryoichiro Kageyama (2013) Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene., Cell reports, Volume 3, Number 1, pp. 1-7

Published in 2013 Jan 31 (Electronic publication in Dec. 7, 2012, midnight )

(Abstract) Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing. The mechanism that regulates the pace of segmentation remains to be determined, but mathematical modeling has predicted that negative feedback with shorter delays would give rise to dampened but more rapid oscillations. Here, we show that reducing the number of introns within the Hes7 gene shortens the delay and results in a more rapid tempo of both Hes7 oscillation and somite segmentation, increasing the number of somites and vertebrae in the cervical and upper thoracic region. These results suggest that the number of introns is important for the appropriate tempo of oscillatory expression and that Hes7 is a key regulator of the pace of the segmentation clock.
(MeSH Terms)

Contact
Ryoichiro Kageyama , Kyoto University , Institute for Virus Research , Kageyama Laboratory
Contributors
Yukiko Harima, Yoshiki Takashima, Yuriko Ueda, Toshiyuki Ohtsuka, and Ryoichiro Kageyama


Dataset List of 15-Harima-GeneExp

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
Download BDML
Download Images
# 781
Datast ID ct_Mmu_PSM
Dataset Kind Image data
Dataset Size 217.0 KB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 782
Datast ID ct_Mmu_PSM
Dataset Kind Quantitative data
Dataset Size 324.7 KB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 783
Datast ID mu_Mmu_PSM
Dataset Kind Image data
Dataset Size 181.1 KB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 784
Datast ID mu_Mmu_PSM
Dataset Kind Quantitative data
Dataset Size 324.7 KB
4D view
SSBD:OMERO
Download BDML
Download Image data