SSBD:database v3

344-Murata-InfectHeart

OMERO gallery,

OMERO index

Project

Title

Influence of persistent SARS-CoV-2 infection on a three- dimensional cardiac model

Description

Patients with chronic cardiomyopathy may have persistent viral infections in their hearts, particularly with SARS-CoV-2, which targets the ACE2 receptor highly expressed in human hearts. This raises concerns about a potential global heart failure pandemic stemming from COVID-19, an SARS-CoV-2 pandemic in near future. Although faced with this healthcare caveat, there is limited research on persistent viral heart infections, and no models have been established. In this study, we created an SARS-CoV-2 persistent infection model using human iPS cell-derived cardiac microtissues (CMTs). Mild infections sustained viral presence without signif- icant dysfunction for a month, indicating persistent infection. However, when exposed to hypoxic conditions mimicking ischemic heart diseases, cardiac function deteriorated alongside intracellular SARS-CoV-2 reacti- vation in cardiomyocytes and disrupted vascular network formation. This study demonstrates that SARS- CoV-2 persistently infects the heart opportunistically causing cardiac dysfunction triggered by detrimental stimuli such as ischemia, potentially predicting a post COVID-19 era heart failure pandemic.

License

CC BY

Released at

Oct. 20, 2025, midnight

Updated at

Funding

Clinical Translational Research Program

# of image datasets

10

Papers

Papers

Paper information: Murata K. et al. Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. iScience. 2023 Dec 22;27(1):108641.,
Pubmed ID: 38299028,
PMCID: PMC10829886,
DOI: https://doi.org/10.1016/j.isci.2023.108641,
URL: https://pubmed.ncbi.nlm.nih.gov/38299028/

Contacts

Contacts

Keizo Tomonaga (Contact) , LabLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciencesoratory for Developmental Dynamics , Kyoto University
Hidetoshi Masumoto (Contact) , Clinical Translational Research Program, Center for Biosystems Dynamics Research , RIKEN
Kozue Murata (Imaging Contributor) , Clinical Translational Research Program, Center for Biosystems Dynamics Research , RIKEN

Biosamples

Organisms

Homo sapiens (NCBI:txid9606)

Strains

Cells

differentiated iPS cells

Cell lines

Ontologies

UBERON

stem cell (CL_0000034)