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Summary of ssbd-repos-000227

Two-color Raman imaging of similar small molecules in living cells by using D-/H-alkynes as Raman tags

Egoshi S, Dodo K, Ohgane K, Sodeoka M. Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules. Org Biomol Chem. 2021 Oct 14;19(38), 8232-8236. doi.org/10.1039/D1OB01479J. PMID: 34528645.

Syusuke Egoshi, Kosuke Dodo, Kenji Ohgane, Mikiko Sodeoka (2021) Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules., Organic & biomolecular chemistry, Volume 19, Number 38, pp. 8232-8236

Published in 2021 Oct 6 (Electronic publication in Oct. 6, 2021, midnight )

• doi: 10.1039/d1ob01479j
• pmid: 34528645
  
• url: https://pubs.rsc.org/en/content/articlelanding/2021/OB/D1OB01479J
  

(Abstract) Alkynes were employed as tags to observe small molecules in cells by Raman microscopy. Herein, simple deuteration was found to shift the vibrational frequency of the alkyne by 135 cm(-1). Two-color Raman imaging of D-alkynes and H-alkynes made it possible to distinguish between and observe similar small molecules in live cells.

• Alkynes[major]