SSBD:database

Summary of 41-Hirata-XChrHiC

Yoshito Hirata, Arisa Oda, Kunihiro Ohta, Kazuyuki Aihara (2016) Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots., Scientific reports, Volume 6, pp. 34982

Published in 2016 Oct 11 (Electronic publication in Oct. 11, 2016, midnight )

• doi: 10.1038/srep34982
• pmid: 27725694
  

(Abstract) Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information.

• Animals
• Cells, Cultured
• Chromosome Structures[major]
• Chromosomes/ultrastructure[major]
• Imaging, Three-Dimensional/methods[major]
• Mice
• Models, Theoretical
• Single-Cell Analysis
• Spatio-Temporal Analysis
• Th1 Cells/chemistry