Yoshito Hirata, Arisa Oda, Kunihiro Ohta, Kazuyuki Aihara (2016) Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots., Scientific reports, Volume 6, pp. 34982
Published in 2016 Oct 11 (Electronic publication in Oct. 11, 2016, midnight )
(Abstract) Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information.(MeSH Terms)