SSBD:database

Summary of 28-Assawachananont-iPSCellTissue

Juthaporn Assawachananont, Michiko Mandai, Satoshi Okamoto, Chikako Yamada, Mototsugu Eiraku, Shigenobu Yonemura, Yoshiki Sasai, Masayo Takahashi (2014) Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice., Stem cell reports, Volume 2, Number 5, pp. 662-74

Published in 2014 May 6 (Electronic publication in April 24, 2014, midnight )

• doi: 10.1016/j.stemcr.2014.03.011
• pmid: 24936453
  

(Abstract) In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a "proof of concept" for retinal sheet transplantation therapy for advanced retinal degenerative diseases.

• Animals
• Cell Culture Techniques
• Collagen/chemistry
• Drug Combinations
• Embryonic Stem Cells/cytology
• Embryonic Stem Cells/transplantation[major]
• Immunohistochemistry
• Induced Pluripotent Stem Cells/cytology
• Induced Pluripotent Stem Cells/transplantation[major]
• Laminin/chemistry
• Mice
• Mice, Inbred C3H
• Mice, Inbred C57BL
• Mitochondria/metabolism
• Mitochondria/pathology
• Proteoglycans/chemistry
• Receptors, Retinoic Acid/antagonists & inhibitors
• Retina/metabolism
• Retina/pathology[major]
• Retinal Degeneration/therapy[major]
• Retinal Degeneration/veterinary
• Transplantation, Homologous