SSBD:database

Summary of 109-Mandai-RPEiPSCell

SSBD:database
109-Mandai-RPEiPSCell
SSBD:database URL
https://ssbd.riken.jp/database/109-Mandai-RPEiPSCell/
Title
Fluorescein angiography images/optical coherence tomography images and micropermetry test of the transplanted eye after transplantation with iPS cell derived retinal pigment epithelium(RPE) sheet
Description
-
Relase date
2019-11-20
Updated date
-
License
CC BY-NC-SA
Kind
Image data based on Experiment
Number of Datasets
15 ( Image datasets: 15, Quantitative data datasets: 0 )
Size of Datasets
29.8 MB ( Image datasets: 29.8 MB, Quantitative data datasets: 0 bytes )
Organism(s)
H. sapiens
Strain(s)
iPS derived retinal pigment epithelial cells
Datatype
iPS derived retinal pigment epithelial cell sheet
Molecular Function (MF)
Biological Process (BP)
retinal pigment epithelium development
Cellular Component (CC)
-
Biological Imaging Method
-
XYZ Scale
XY: 12.02 micrometer/pixel, Z: NA, XY: 12.23 micrometer/pixel, Z: NA, XY: 5.78 micrometer/pixel, Z: NA, XY: 12.05 micrometer/pixel, Z: NA, XY: 6.04 micrometer/pixel, Z: NA, XY: 11.83 micrometer/pixel, Z: NA, XY: 5.86 micrometer/pixel, Z: NA, XY: 11.68 micrometer/pixel, Z: NA, XY: NA micrometer/pixel, Z: NA, XY: 5.82 micrometer/pixel, Z: NA, XY: 5.93 micrometer/pixel, Z: NA
T scale
-
Image Acquisition
Experiment type
Immunofluorescence, Other
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Related paper(s)

Michiko Mandai, Akira Watanabe, Yasuo Kurimoto, Yasuhiko Hirami, Chikako Morinaga, Takashi Daimon, Masashi Fujihara, Hiroshi Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, Hiroyuki Kamao, Sunao Sugita, Akishi Onishi, Tomoko Ito, Kanako Fujita, Shin Kawamata, Masahiro J Go, Chikara Shinohara, Ken-Ichiro Hata, Masanori Sawada, Midori Yamamoto, Sachiko Ohta, Yasuo Ohara, Kenichi Yoshida, Junko Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, Seishi Ogawa, Shinya Yamanaka, Masayo Takahashi (2017) Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration., The New England journal of medicine, Volume 376, Number 11, pp. 1038-1046

Published in 2017 Mar 16

(Abstract) We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with advanced neovascular age-related macular degeneration and were differentiated into RPE cells. The RPE cells and the iPSCs from which they were derived were subject to extensive testing. A surgery that included the removal of the neovascular membrane and transplantation of the autologous iPSC-derived RPE cell sheet under the retina was performed in one of the patients. At 1 year after surgery, the transplanted sheet remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present. (Funded by Highway Program for Realization of Regenerative Medicine and others; University Hospital Medical Information Network Clinical Trials Registry [UMIN-CTR] number, UMIN000011929 .).
(MeSH Terms)
Contact
Masayo Takahashi , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Retinal Regeneration
Contributors
Michiko Mandai, Akira Watanabe, Yasuo Kurimoto, Yasuhiko Hirami, Chikako Morinaga, Takashi Daimon, Masashi Fujihara, Hiroshi Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, Hiroyuki Kamao, Sunao Sugita, Akishi Onishi, Tomoko Ito, Kanako Fujita, Shin Kawamata, Masahiro J. Go, Chikara Shinohara, Ken-ichiro Hata, Masanori Sawada, Midori Yamamoto, Sachiko Ohta, Yasuo Ohara, Kenichi Yoshida, Junko Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, Seishi Ogawa, Shinya Yamanaka, Masayo Takahashi

Dataset List of 109-Mandai-RPEiPSCell

#
Dataset ID
Kind
Size
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SSBD:OMERO
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# 4435
Datast ID figS10B_1Y_2.56min
Dataset Kind Image data
Dataset Size 716.6 KB
4D view
SSBD:OMERO
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# 4436
Datast ID figS10B_1Y_7.23min
Dataset Kind Image data
Dataset Size 1.7 MB
4D view
SSBD:OMERO
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# 4437
Datast ID figS10B_1Y_25sec
Dataset Kind Image data
Dataset Size 92.6 KB
4D view
SSBD:OMERO
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# 4438
Datast ID figS10B_6M_1.34min
Dataset Kind Image data
Dataset Size 1.7 MB
4D view
SSBD:OMERO
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# 4439
Datast ID figS10B_6M_8.05min
Dataset Kind Image data
Dataset Size 1.7 MB
4D view
SSBD:OMERO
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# 4440
Datast ID figS10B_6M_33sec
Dataset Kind Image data
Dataset Size 75.3 KB
4D view
SSBD:OMERO
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# 4441
Datast ID figS11_1week
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4442
Datast ID figS11_3days
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4443
Datast ID figS11_3months
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4444
Datast ID figS11_4weeks
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4445
Datast ID figS11_6months
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4446
Datast ID figS13B_1Y
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
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# 4447
Datast ID figS13B_2nd
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
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# 4448
Datast ID figS13B_2Y
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
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# 4449
Datast ID figS13B_3Y
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
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Download Image data