Summary of 109-Mandai-RPEiPSCell
Title
Fluorescein angiography images/optical coherence tomography images and micropermetry test of the transplanted eye after transplantation with iPS cell derived retinal pigment epithelium(RPE) sheet
Kind
Image data
based on Experiment
Number of Datasets
15
( Image datasets: 15,
Quantitative data datasets: 0 )
Size of Datasets
29.8 MB
( Image datasets: 29.8 MB,
Quantitative data datasets: 0 bytes )
Strain(s)
iPS derived retinal pigment epithelial cells
Datatype
iPS derived retinal pigment epithelial cell sheet
Biological Process (BP)
retinal pigment epithelium development
Cellular Component (CC)
-
Biological Imaging Method
-
XYZ Scale
XY: 12.23 micrometer/pixel, Z: NA, XY: 11.68 micrometer/pixel, Z: NA, XY: 5.93 micrometer/pixel, Z: NA, XY: 5.82 micrometer/pixel, Z: NA, XY: 6.04 micrometer/pixel, Z: NA, XY: 5.78 micrometer/pixel, Z: NA, XY: 11.83 micrometer/pixel, Z: NA, XY: 12.02 micrometer/pixel, Z: NA, XY: 12.05 micrometer/pixel, Z: NA, XY: 5.86 micrometer/pixel, Z: NA, XY: NA micrometer/pixel, Z: NA
Image Acquisition
Experiment type
Immunofluorescence, Other
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Related paper(s)
Michiko Mandai, Akira Watanabe, Yasuo Kurimoto, Yasuhiko Hirami, Chikako Morinaga, Takashi Daimon, Masashi Fujihara, Hiroshi Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, Hiroyuki Kamao, Sunao Sugita, Akishi Onishi, Tomoko Ito, Kanako Fujita, Shin Kawamata, Masahiro J Go, Chikara Shinohara, Ken-Ichiro Hata, Masanori Sawada, Midori Yamamoto, Sachiko Ohta, Yasuo Ohara, Kenichi Yoshida, Junko Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, Seishi Ogawa, Shinya Yamanaka, Masayo Takahashi (2017) Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration., The New England journal of medicine, Volume 376, Number 11, pp. 1038-1046
Published in 2017 Mar 16
(Abstract) We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with advanced neovascular age-related macular degeneration and were differentiated into RPE cells. The RPE cells and the iPSCs from which they were derived were subject to extensive testing. A surgery that included the removal of the neovascular membrane and transplantation of the autologous iPSC-derived RPE cell sheet under the retina was performed in one of the patients. At 1 year after surgery, the transplanted sheet remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present. (Funded by Highway Program for Realization of Regenerative Medicine and others; University Hospital Medical Information Network Clinical Trials Registry [UMIN-CTR] number, UMIN000011929 .).
(MeSH Terms)
Contact
Masayo Takahashi
, RIKEN
, Center for Biosystems Dynamics Research
, Laboratory for Retinal Regeneration
Contributors
Michiko Mandai, Akira Watanabe, Yasuo Kurimoto, Yasuhiko Hirami, Chikako Morinaga, Takashi Daimon, Masashi Fujihara, Hiroshi Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, Hiroyuki Kamao, Sunao Sugita, Akishi Onishi, Tomoko Ito, Kanako Fujita, Shin Kawamata, Masahiro J. Go, Chikara Shinohara, Ken-ichiro Hata, Masanori Sawada, Midori Yamamoto, Sachiko Ohta, Yasuo Ohara, Kenichi Yoshida, Junko Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, Seishi Ogawa, Shinya Yamanaka, Masayo Takahashi
SSBD:OMERO.gallery Project
SSBD:OMERO Project
Dataset List of 109-Mandai-RPEiPSCell
#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
Download BDML
Download Images
Dataset Kind
Image data
Dataset Size
716.6 KB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (209.0 KB)
Dataset Kind
Image data
Dataset Size
1.7 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (469.7 KB)
Dataset Kind
Image data
Dataset Size
92.6 KB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (76.0 KB)
Dataset Kind
Image data
Dataset Size
1.7 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (483.9 KB)
Dataset Kind
Image data
Dataset Size
1.7 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (449.5 KB)
Dataset Kind
Image data
Dataset Size
75.3 KB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (58.7 KB)
Dataset Kind
Image data
Dataset Size
1.5 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (278.8 KB)
Dataset Kind
Image data
Dataset Size
1.5 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (440.7 KB)
Dataset Kind
Image data
Dataset Size
1.5 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (400.8 KB)
Dataset Kind
Image data
Dataset Size
1.5 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (322.6 KB)
Dataset Kind
Image data
Dataset Size
1.5 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (317.0 KB)
Dataset Kind
Image data
Dataset Size
4.1 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (1.6 MB)
Dataset Kind
Image data
Dataset Size
4.1 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (1.7 MB)
Dataset Kind
Image data
Dataset Size
4.1 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (1.6 MB)
Dataset Kind
Image data
Dataset Size
4.1 MB
4D view
4D View
SSBD:OMERO
gallery
index
Download BDML
zip
Download Image data
zip (1.7 MB)