Detail of Supfig5_day180
Project
Title
CT images of the bioengineered tooth development 180 days after autologous transplantaion into the mandible
Description
NA
Release, Updated
2019-11-20
License
CC BY
Kind
Image data
based on Experiment
File Formats
Data size
18.2 KB
Datatype
tooth development
Molecular Function (MF)
Biological Process (BP)
odontogenesis
(
GO:0042476
)
Cellular Component (CC)
-
Biological Imaging Method
XYZ Scale
XY: NA micrometer/pixel, Z:NA
T scale
-
Image Acquisition
Experiment type
Other
Microscope type
Other
Acquisition mode
BrightField
Contrast method
Darkfield
Microscope model
PLANMECA ProMax 3D Max
Detector model
-
Objective model
-
Filter set
-
Summary of Methods
See details in Ono et al. (2017) Sci Rep, 7: 44522.
Related paper(s)
Mitsuaki Ono, Masamitsu Oshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji, Takuo Kuboki (2017) Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model., Scientific reports, Volume 7, pp. 44522
Published in 2017 Mar 16 (Electronic publication in March 16, 2017, midnight )
- doi: 10.1038/srep44522
-
pmid: 28300208
(Abstract) Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine.(MeSH Terms)
- Animals
- Biomedical Engineering/trends
- Dogs
- Humans
- Odontogenesis/physiology
- Regeneration/physiology
- Regenerative Medicine[major]
- Stem Cells
- Tissue Engineering[major]
- Tooth/growth & development
- Tooth/transplantation[major]
- Tooth Eruption
- Tooth Germ/physiology
- Tooth Germ/transplantation[major]
- Tooth Replantation
- Transplantation, Autologous/methods
Contact
Takuo Kuboki
, Okayama University
, Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Contributors
Mitsuaki Ono, Masamitsu Oshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji, Takuo Kuboki
OMERO Dataset
OMERO Project
Source