Detail of Fig5E_VB_tofacitinib
Project
SSBD:Repository
Title
Z-series images of actin filaments in VB in SARS-CoV-2-infected devices with the administration of tofacitinib
Description
Z-series images of actin filaments in vascular bed (VB) in SARS-CoV-2-infected devices with the administration of tofacitinib, a JAK/STAT inhibitor. In the 3D culture device, vascular bed and bronchial organoids were co-cultured, and the vitrus was infected to the bronchial organoids. The inhibitor was applied to the VB existing channel. Channel1: DAPI, Channel2: Alexa Fluor 647 labeled phalloidin Channel3: GFP, Channel4: ICAM1, Channel5: Differential interference image
Release, Updated
2025-11-26
License
CC BY
Kind
Image data
File Formats
.tif
Data size
45.9 MB
Datatype
-
Molecular Function (MF)
Biological Process (BP)
viral process
Cellular Component (CC)
nucleus
,
actin cytoskeleton
Biological Imaging Method
confocal microscopy
(
Fbbi:00000251
)
X scale
1.24 micrometer
Y scale
1.24 micrometer
Z scale
3.22 micrometer
T scale
-
Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Summary of Methods
Fujimoto K, Kameda Y, Nagano Y, Deguchi S, Yamamoto T, Krol RP, Gee P, Matsumura Y, Okamoto T, Nagao M, Takayama K, Yokokawa R. SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids. Lab Chip . 2024 Aug 6;24(16):3863-3879.
Related paper(s)
Contact
Ryuji Yokokawa, Kazuo Takayama
, Kyoto University, Kyoto University
Contributors
OMERO Project