Z-series images of bilaminoids generated spontaneously by the mixture of naive hPSCs (human pluripotent stem cells) and nHyCs (naive hPSC-derived hypoblast-like cells expressing GFP) on day 9. After fixation, the bilaminoid was stained for ISL1, GATA3, and DAPI.
Okubo T, Rivron N, Kabata M, Masaki H, Kishimoto K, Semi K, Nakajima-Koyama M, Kunitomi H, Kaswandy B, Sato H, Nakauchi H, Woltjen K, Saitou M, Sasaki E, Yamamoto T, Takashima Y. Hypoblast from human pluripotent stem cells regulates epiblast development. Nature. 2024 Feb;626(7998):357-366.
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Takuya Yamamoto, Yasuhiro Takashima
, Kyoto University, Kyoto University
, Center for iPS Cell Research and Application,, Center for iPS Cell Research and Application,
, Center for iPS Cell Research and Application,, Center for iPS Cell Research and Application,