SSBD:database

Key Organism Strain Cell Line Gene Symbol Protein name Protein tag Reporter Project ID Dataset ID Title Description Data Type Gene Ontology Biological Imaging Methods Method Summary Paper Information Medical Subject Headlines Person

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386-Takahashi-EarIL31RA

https://ssbd.riken.jp/database/386-Takahashi-EarIL31RA/

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ssbd-repos-000386

https://ssbd.riken.jp/repository/386/

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Immunofluorescence images of nerve fiber and IL-31 receptors in the mouse ear skin

IL-31 receptor blockade suppresses pruritus of atopic dermatitis. However, cell-type-specific contributions of IL-31 receptor to itch, its expression mechanism, and the downstream signaling pathway to induce itch remain unknown. In this report, using conditional knockout mice, the authors demonstrate that IL-31-induced itch requires sensory neuronal IL-31 receptor and STAT3. They find that IL-31 receptor expression is dependent on STAT3 in sensory neurons. In addition, pharmacological experiments suggest that STAT3 activation is important for the itch-inducing signaling downstream of the IL-31 receptor. A cutaneous IL-31 injection induces the nuclear accumulation of activated STAT3 first in sensory neurons that abundantly express IL-31 receptor and then in other itch-transmitting neurons. IL-31 enhances itch induced by various pruritogens including even chloroquine. Finally, pruritus associated with dermatitis is partially dependent on sensory neuronal IL-31 receptor and strongly on sensory neuronal STAT3. Thus, sensory neuronal STAT3 is essential for IL-31-induced itch and further contributes to IL-31-independent inflammatory itch.

2025-11-28

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CC BY-SA

Image data based on Experiment

10 ( Image datasets: 10, Quantitative data datasets: 0 )

3.5 GB ( Image datasets: 3.5 GB, Quantitative data datasets: 0 bytes )

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Mus musculus

B6.129-Scn10a^{tm2(cre)Jwo}/H, B6.Cg-Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/J, Il31ra-flox, B6.129-Scn10a^{tm2(cre)Jwo}/H, B6.Cg-Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/J

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axon, nucleus

confocal microscopy

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Takaharu Okada , RIKEN IMS , Laboratory for Tissue Dynamics , Laboratory for Tissue Dynamics

Sonoko Takahashi, Sotaro Ochiai, Noriko Takahashi, Manabu Nakayama, Takaharu Okada

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