Summary of 254-Seita-GrowthDyn

SSBD:database
SSBD:database URL
Title
Time-lapse images of L1210 cells growth and division in the mammalian mother machine microfluidic device.
Description
-
Relase date
2023-08-29
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
146 ( Image datasets: 146, Quantitative data datasets: 0 )
Size of Datasets
248.4 GB ( Image datasets: 248.4 GB, Quantitative data datasets: 0 bytes )

Organism(s)
Mus musculus
Cell lines(s)
L1210 cell

Datatype
-
Molecular Function (MF)
Biological Process (BP)
growth, cell division
Cellular Component (CC)
nucleus
Biological Imaging Method
time lapse microscopy
T scale
10 minutes of time interval

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Akihisa Seita, Hidenori Nakaoka, Reiko Okura, Yuichi Wakamoto (2021) Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug., PloS one, Volume 16, Number 2, pp. e0236534

Published in 2021 (Electronic publication in Feb. 1, 2021, midnight )

(Abstract) Cancer cell populations consist of phenotypically heterogeneous cells. Growing evidence suggests that pre-existing phenotypic differences among cancer cells correlate with differential susceptibility to anticancer drugs and eventually lead to a relapse. Such phenotypic differences can arise not only externally driven by the environmental heterogeneity around individual cells but also internally by the intrinsic fluctuation of cells. However, the quantitative characteristics of intrinsic phenotypic heterogeneity emerging even under constant environments and their relevance to drug susceptibility remain elusive. Here we employed a microfluidic device, mammalian mother machine, for studying the intrinsic heterogeneity of growth dynamics of mouse lymphocytic leukemia cells (L1210) across tens of generations. The generation time of this cancer cell line had a distribution with a long tail and a heritability across generations. We determined that a minority of cell lineages exist in a slow-cycling state for multiple generations. These slow-cycling cell lineages had a higher chance of survival than the fast-cycling lineages under continuous exposure to the anticancer drug Mitomycin C. This result suggests that heritable heterogeneity in cancer cells' growth in a population influences their susceptibility to anticancer drugs.
(MeSH Terms)

Contact
Yuichi Wakamoto, Hidenori Nakaoka , The University of Tokyo, Kyoto University , Graduate School of Arts and Sciences , Graduate School of Biostudies
Contributors


Dataset List of 254-Seita-GrowthDyn

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
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# 10840
Datast ID Fig1_TL_L1210_1
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10841
Datast ID Fig1_TL_L1210_2
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10842
Datast ID Fig1_TL_L1210_3
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10843
Datast ID Fig1_TL_L1210_4
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10844
Datast ID Fig1_TL_L1210_5
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10845
Datast ID Fig1_TL_L1210_6
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10846
Datast ID Fig1_TL_L1210_7
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10847
Datast ID Fig1_TL_L1210_8
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10848
Datast ID Fig1_TL_L1210_9
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10849
Datast ID Fig1_TL_L1210_10
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10850
Datast ID Fig1_TL_L1210_11
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10851
Datast ID Fig1_TL_L1210_12
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10852
Datast ID Fig1_TL_L1210_13
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10853
Datast ID Fig1_TL_L1210_14
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10854
Datast ID Fig1_TL_L1210_15
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10855
Datast ID Fig1_TL_L1210_16
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10856
Datast ID Fig1_TL_L1210_17
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10857
Datast ID Fig1_TL_L1210_18
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10858
Datast ID Fig1_TL_L1210_19
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10859
Datast ID Fig1_TL_L1210_20
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10860
Datast ID Fig1_TL_L1210_21
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10861
Datast ID Fig1_TL_L1210_22
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10862
Datast ID Fig1_TL_L1210_23
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10863
Datast ID Fig1_TL_L1210_24
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10864
Datast ID Fig1_TL_L1210_25
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10865
Datast ID Fig1_TL_L1210_26
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10866
Datast ID Fig1_TL_L1210_27
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10867
Datast ID Fig1_TL_L1210_28
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10868
Datast ID Fig1_TL_L1210_29
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10869
Datast ID Fig1_TL_L1210_30
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10870
Datast ID Fig1_TL_L1210_31
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10871
Datast ID Fig1_TL_L1210_32
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10872
Datast ID Fig1_TL_L1210_33
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10873
Datast ID Fig1_TL_L1210_34
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10874
Datast ID Fig1_TL_L1210_35
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10875
Datast ID Fig1_TL_L1210_36
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10876
Datast ID Fig1_TL_L1210_37
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10877
Datast ID Fig1_TL_L1210_38
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10878
Datast ID Fig1_TL_L1210_39
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10879
Datast ID Fig1_TL_L1210_40
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10880
Datast ID Fig1_TL_L1210_41
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10881
Datast ID Fig1_TL_L1210_42
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10882
Datast ID Fig1_TL_L1210_43
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10883
Datast ID Fig1_TL_L1210_44
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10884
Datast ID Fig1_TL_L1210_45
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10885
Datast ID Fig1_TL_L1210_46
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10886
Datast ID Fig1_TL_L1210_47
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10887
Datast ID Fig1_TL_L1210_48
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10888
Datast ID Fig1_TL_L1210_49
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10889
Datast ID Fig1_TL_L1210_50
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10890
Datast ID Fig1_TL_L1210_51
Dataset Kind Image data
Dataset Size 1.4 GB
4D view
SSBD:OMERO
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# 10891
Datast ID Fig3_50nM_MMC_TL_1
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10892
Datast ID Fig3_50nM_MMC_TL_2
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10893
Datast ID Fig3_50nM_MMC_TL_3
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10894
Datast ID Fig3_50nM_MMC_TL_4
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10895
Datast ID Fig3_50nM_MMC_TL_5
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10896
Datast ID Fig3_50nM_MMC_TL_6
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10897
Datast ID Fig3_50nM_MMC_TL_7
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10898
Datast ID Fig3_50nM_MMC_TL_8
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10899
Datast ID Fig3_50nM_MMC_TL_9
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10900
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10901
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10902
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10903
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10904
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10905
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10906
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10907
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10908
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10909
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10910
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10911
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10912
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10913
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10914
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10915
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10916
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10917
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10918
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10919
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10920
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10921
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10922
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10923
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10924
Dataset Kind Image data
Dataset Size 1.8 GB
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SSBD:OMERO
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# 10925
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10926
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10927
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10928
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10929
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10930
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10931
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10932
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10933
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10934
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10935
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10936
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10937
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10938
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10939
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10940
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10941
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10942
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10943
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10944
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10945
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10946
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10947
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10948
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10949
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10950
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10951
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10952
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10953
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10954
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10955
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10956
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10957
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10958
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10959
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10960
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10961
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10962
Dataset Kind Image data
Dataset Size 1.8 GB
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SSBD:OMERO
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# 10963
Dataset Kind Image data
Dataset Size 1.8 GB
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SSBD:OMERO
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# 10964
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10965
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10966
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10967
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10968
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10969
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10970
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10971
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10972
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10973
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10974
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10975
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10976
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10977
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10978
Dataset Kind Image data
Dataset Size 1.8 GB
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SSBD:OMERO
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# 10979
Dataset Kind Image data
Dataset Size 1.8 GB
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SSBD:OMERO
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# 10980
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10981
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10982
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10983
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10984
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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# 10985
Dataset Kind Image data
Dataset Size 1.8 GB
4D view
SSBD:OMERO
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