SSBD:database

Project ID

402-Tasaka-parentOFCactivity

Project SID

402

Title

Neuronal activity in orbitofrontal cortex during some parental stages

Description

Maternal behaviors, which are crucial for the survival of mammalian infants, require the coordinated operation of multiple brain regions to process infant cues, make decisions, and execute motor plans. Although these processes likely demand higher cognitive functions, the prefrontal areas that regulate limbic parental programs remains poorly understood. Here, we show that the orbitofrontal cortex (OFC) excitatory projection neurons promote alloparental caregiving behaviors in female mice. By chronic microendoscopy, we observed robust yet adaptable representations of pup-directed anticipatory and motor-related activities within the OFC. Some of these plastic responses were significantly overlapped with those related to nonsocial reward signals. The inactivation of OFC output reduced the phasic activities of midbrain dopamine (DA) neurons specifically tied to pup retrieval and impaired the modulation of DA release to the ventral striatum during the acquisition of alloparental behaviors. These findings suggest that the OFC transiently boosts DA activity during the acquisition phase, thereby facilitating the manifestation of alloparental behaviors.

Submission Date

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Opened Date

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Release Date

2026-06-26

Update Date

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Kind

License

Project URL

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Project DOI

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Metadata Version

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Template Version

3.0.3

Funding Information

This work was supported by the JST PRESTO program JPMJPR21S7 (G.T.), JSPS KAKENHI 20 K15941 (G.T.), RIKEN Incentive grant (G.T.), RIKEN Diversity grant (G.T.), AMED Brain/MINDS program JP21dm0207113 (Ka.K.), JSPS KAKENHI 21H02587 and 23H04945 (K.M.), Takeda Science Foundation Research Grant (K.M.), and RIKEN BDR Stage Transition Project (K.M.).

Total

48 files / 672.0 GB

Image datasets

zipped 24 files / 243.5 GB, raw image 24 files / 428.5 GB, total 48 files / 672.0 GB

Quantitative datasets

zipped 0 files / 0 bytes, raw bdml 0 files / 0 bytes, total 0 files / 0 bytes

Organism

Strain

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Cell

Cell line

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MeSH

Anatomical Entity

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UBERON

Biological Process

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Cellular Component

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Molecular Function

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Medical Subject Headings

Method involved in biological imaging