SSBD:database

Project ID

327-Okuzumi-synuclein

Project SID

327

Title

TEM images of alpha-synuclein released in serum

Description

Abnormal alpha-synuclein aggregation is a key pathological feature of a group of neurodegenerative diseases known as synucleinopathies, which include Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. The pathogenic beta-sheet seed conformation of alpha-synuclein is found in various tissues, suggesting potential as a biomarker, but few studies have been able to reliably detect these seeds in serum samples. In this study, the authors developed a modified assay system, called immunoprecipitation-based real-time quaking-induced conversion (IP/RT-QuIC), which enables the detection of pathogenic α-synuclein seeds in the serum of individuals with synucleinopathies.

Submission Date

2024-05-07

Opened Date

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Release Date

2025-01-31

Update Date

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Kind

License

Project URL

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Project DOI

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Metadata Version

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Template Version

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Funding Information

This work was supported by the Japan Agency for Medical Research and Development (AMED) (20dm0107156 and 21wm0425015 to T.H. and A.O. and 21ak0101112 to T.H. and N.H.); the Multicenter Alliance for Brain Biomarkers (21dk0207055 to T.H., 21dm0207070 to N.H. and 20dm0107140 to N.N.); Grants-in-Aid for Scientific Research (21H04820 to N.H., 21K07424 to T.H., 19K16928 to A.O. and 20K22693 to S.U.) from the Japan Society for the Promotion of Science; the Visionary Council on the Moonshot Research and Development Program (JPMJMS2024-5 to N.H.); grants-in-aid from the Research Committee of CNS Degenerative Disease, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health, Labor, and Welfare Sciences Research Grants; the Ministry of Health, Labour and Welfare, Japan, to N.H.; the Setsuro Fujii Memorial, Osaka Foundation for Promotion of Fundamental Medical Research, to T.H.; grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to G.M. (17K07098 and 20H05333) for Scientific Research on Innovative Areas ‘Multimode autophagy’; the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD) funded by the Luxembourg National Research Fund (FNR; NCER13/BM/11264123); and the PEARL program (PEARL /P13/6682797 to R.K. and PEARL P16/BM/11192868 to M.M.).

Total

604 files / 863.7 MB

Image datasets

zipped 32 files / 401.6 MB, raw image 572 files / 462.1 MB, total 604 files / 863.7 MB

Quantitative datasets

zipped 0 files / 0 bytes, raw bdml 0 files / 0 bytes, total 0 files / 0 bytes

Organism

Strain

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Cell

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Cell line

MeSH

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Anatomical Entity

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UBERON

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Biological Process

Cellular Component

Molecular Function

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Medical Subject Headings

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Method involved in biological imaging