SSBD:database

Project ID

334-Hashimoto-SARSorganoid

Title

Inhibition of SARS-CoV-2 virus infection to human airway organoids by autophagy-related compounds.

Description

To deal with the broad spectrum of coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that threaten human health, it is essential to not only drugs develop that target viral proteins but also consider drugs that target host proteins/cellular processes to protect them from being hijacked for viral infection and replication. To this end, it has been reported that autophagy is deeply involved in coronavirus infection. In this study, they used airway organoids to screen a chemical library of autophagic modulators to identify compounds that could potentially be used to fight against infections by a broad range of coronaviruses. Among the 80 autophagy-related compounds tested, cycloheximide and thapsigargin reduced SARS-CoV-2 infection efficiency in a dose-dependent manner.

Release Date

2024-11-25

Update Date

-

License

CC BY

Version

1.0.0

Method Summary

See details in Hashimoto R, et. al. Mol Pharm. 2023 Apr 3;20(4):2276-2287.

Paper DOI

https://doi.org/10.1021/acs.molpharmaceut.3c00114

Paper URL

https://pubmed.ncbi.nlm.nih.gov/36946991/

Kind

Organism

Strain

-

Cell line

-

Biological Process

Cellular Component

Medical Subject Headings

-

Method involved in biological imaging