280-Uyama-RetinaGraft
Author reviewedImages of OCT and FAG after transplantation of monkey iPSC-retina
Project ID
280-Uyama-RetinaGraft
Title
Images of OCT and FAG after transplantation of monkey iPSC-retina
Description
Transplantation of embryonic/induced pluripotent stem cell-derived retina (ESC/iPSC-retina) restores host retinal ganglion cell light re- sponses in end-stage retinal degeneration models with host-graft synapse formation. The authors studied the immunological features of iPSC- retina transplantation using major histocompatibility complex (MHC)-homozygote monkey iPSC-retinas in monkeys with laser-induced retinal degeneration in MHC-matched and -mismatched transplantation. MHC-mismatched transplantation without immune suppression showed no evident clinical signs of rejection and histologically showed graft maturation without lymphocytic infiltration, although immunological tests using peripheral blood monocytes suggested subclinical rejection in three of four MHC-mismatched monkeys.
Release Date
2024-12-14
Update Date
-
License
Version
1.0.0
Method Summary
See details in Uyama H, et. al. Stem Cell Reports. 2022 Nov 8;17(11):2392-2408.
Kind
Image data
Total
84 files / 250.7 MB
Image datasets
zipped 22 files / 122.2 MB, raw image 62 files / 128.5 MB, total 84 files / 250.7 MB
Quantitative datasets
zipped 0 files / 0 bytes, raw bdml 0 files / 0 bytes, total 0 files / 0 bytes
Organism
Macaca fascicularis
(
NCBITaxon:9541
)
Strain
-
Cell line
-
Biological Process
retina homeostasis
(
GO:0001895
)
Cellular Component
-
Medical Subject Headings
-
Method involved in biological imaging
fluorescein leakage on fluorescein angiography
OCT
(
FBbi:00000371
)
Image datasets
22
Quantitative datasets
0
Paper DOI / Paper URL
OMERO.gallery
People
Contact
Hirofumi Uyama
Kobe City Eye Hospital
Department of Ophthalmology
-
2-1-8 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Michiko Mandai
Kobe City Eye Hospital
Department of Ophthalmology
-
2-1-8 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Imaging dataset contributor
Hirofumi Uyama
Hung-Ya Tu
Sunao Sugita
Suguru Yamasaki
Yasuo Kurimoto
Take Matsuyama
Takehito Watanabe
Michiko Mandai
Quantitative dataset contributor
-
Datasets
Thumbnail
Dataset
Organism
Kind / Links
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, 3M, and 6M after transplantation of monkey iPSC-retina.
Images of OCT (optical coherence tomography) 2W, 1M, 3M, and 6M after transplantation of monkey iPSC-retina.
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, and 3M after transplantation of monkey iPSC-retina on left eye.
Images of OCT (optical coherence tomography) 2W, 1M, and 3M after transplantation of monkey iPSC-retina on left eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 1M, 3M, and 6M after transplantation of monkey iPSC-retina on right eye.
Images of OCT (optical coherence tomography) 1M, 3M, and 6M after transplantation of monkey iPSC-retina on right eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of OCT (optical coherence tomography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of OCT (optical coherence tomography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of OCT (optical coherence tomography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of OCT (optical coherence tomography) 2W, 1M, and 2M after transplantation of monkey iPSC-retina on left eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 1M, 3M, and 5M after transplantation of monkey iPSC-retina on right eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2 weeks after transplantation of monkey iPSC-retina on right eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 1M, 3M, and 5M after transplantation of monkey iPSC-retina on right eye.
Images of FAG (fluorescein leakage on fluorescein angiography) 2 weeks and 1 month after transplantation of monkey iPSC-retina on right eye.
Images of OCT (optical coherence tomography) 1M, 3M, and 5M after transplantation of monkey iPSC-retina on right eye.
Images of OCT (optical coherence tomography) 2 weeks after transplantation of monkey iPSC-retina on right eye.
Images of OCT (optical coherence tomography) 1M, 3M, and 5M after transplantation of monkey iPSC-retina on right eye.
Images of OCT (optical coherence tomography) 2 weeks and 1 month after transplantation of monkey iPSC-retina on right eye.