PROX1+ and CDX2+ cells form distinct cell populations in colorectal cancer.
Description
The mutually exclusive staining of cycling CDX2+ and non-cycling PROX1+ cells in human CRC organoids, mouse xenografted tumors, and human CRC specimens. Inhibition of mTORC1 triggers conversion from CDX2+ cells to PROX1+ cells in human CRC organoids and mouse xenografted tumors.