Summary of 209-Kimura-SkinMorphology

SSBD:database
SSBD:database URL
Title
HE staining images of human skin and the THS model after 1, 3, 5 and 7 days of culture at the air–liquid interface.
Description
-
Relase date
2022-11-23
Updated date
-
License
CC-BY
Kind
Image data based on Experiment
Number of Datasets
2 ( Image datasets: 2, Quantitative data datasets: 0 )
Size of Datasets
1.2 GB ( Image datasets: 1.2 GB, Quantitative data datasets: 0 bytes )

Organism(s)
Homo sapiens

Datatype
-
Molecular Function (MF)
Biological Process (BP)
skin epidermis development
Cellular Component (CC)
Biological Imaging Method
confocal microscopy
X scale
0.2194382 micrometer/pixel
Y scale
0.2194382 micrometer/pixel
Z scale
-
T scale
-

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Shun Kimura, Ayako Tsuchiya, Miho Ogawa, Miki Ono, Nao Suda, Kaori Sekimoto, Makoto Takeo, Takashi Tsuji (2020) Tissue-scale tensional homeostasis in skin regulates structure and physiological function., Communications biology, Volume 3, Number 1, pp. 637

Published in 2020 Oct 30 (Electronic publication in Oct. 30, 2020, midnight )

(Abstract) Tensional homeostasis is crucial for organ and tissue development, including the establishment of morphological and functional properties. Skin plays essential roles in waterproofing, cushioning and protecting deeper tissues by forming internal tension-distribution patterns, which involves aligning various cells, appendages and extracellular matrices (ECMs). The balance of traction force is thought to contribute to the formation of strong and pliable physical structures that maintain their integrity and flexibility. Here, by using a human skin equivalent (HSE), the horizontal tension-force balance of the dermal layer was found to clearly improve HSE characteristics, such as the physical relationship between cells and the ECM. The tension also promoted skin homeostasis through the activation of mechano-sensitive molecules such as ROCK and MRTF-A, and these results compared favourably to what was observed in tension-released models. Tension-induced HSE will contribute to analyze skin physiological functions regulated by tensional homeostasis as an alternative animal model.
(MeSH Terms)

Contact
Takashi Tsuji , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Organ Regeneration
Contributors


Dataset List of 209-Kimura-SkinMorphology

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
Download BDML
Download Images
# 7731
Datast ID Fig1f_HE_humanskin
Dataset Kind Image data
Dataset Size 323.4 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7732
Dataset Kind Image data
Dataset Size 860.4 MB
4D view
SSBD:OMERO
Download BDML
Download Image data