SSBD:database

Detail of Fig1f_HE_THS_airliquid

Shun Kimura, Ayako Tsuchiya, Miho Ogawa, Miki Ono, Nao Suda, Kaori Sekimoto, Makoto Takeo, Takashi Tsuji (2020) Tissue-scale tensional homeostasis in skin regulates structure and physiological function., Communications biology, Volume 3, Number 1, pp. 637

Published in 2020 Oct 30 (Electronic publication in Oct. 30, 2020, midnight )

• doi: 10.1038/s42003-020-01365-7
• pmid: 33127987
  

(Abstract) Tensional homeostasis is crucial for organ and tissue development, including the establishment of morphological and functional properties. Skin plays essential roles in waterproofing, cushioning and protecting deeper tissues by forming internal tension-distribution patterns, which involves aligning various cells, appendages and extracellular matrices (ECMs). The balance of traction force is thought to contribute to the formation of strong and pliable physical structures that maintain their integrity and flexibility. Here, by using a human skin equivalent (HSE), the horizontal tension-force balance of the dermal layer was found to clearly improve HSE characteristics, such as the physical relationship between cells and the ECM. The tension also promoted skin homeostasis through the activation of mechano-sensitive molecules such as ROCK and MRTF-A, and these results compared favourably to what was observed in tension-released models. Tension-induced HSE will contribute to analyze skin physiological functions regulated by tensional homeostasis as an alternative animal model.

• Amides/pharmacology
• Animals
• Biomechanical Phenomena
• Cell Adhesion
• Epidermis/physiology
• Extracellular Matrix/physiology
• Female
• Fibroblasts/physiology
• Gene Expression Regulation
• Homeostasis
• Humans
• Keratinocytes/cytology
• Keratinocytes/physiology
• Mice, Inbred C57BL
• Models, Biological
• Pyridines/pharmacology
• Skin/chemistry
• Skin/cytology[major]
• Skin/drug effects[major]
• Skin Physiological Phenomena[major]
• Stress, Mechanical
• Tissue Culture Techniques