Summary of 196-Sueda-GeneExpReg

SSBD:database
SSBD:database URL
Title
Images of Hes1 or Ascl1 expression regulating neural stem cells development in the adult mouse brain.
Description
-
Relase date
2022-03-31
Updated date
-
License
CC-BY
Kind
Image data based on Experiment
Number of Datasets
24 ( Image datasets: 24, Quantitative data datasets: 0 )
Size of Datasets
2.1 GB ( Image datasets: 2.1 GB, Quantitative data datasets: 0 bytes )

Organism(s)
Mus musculus
Gene symbol(s)
Ascl1, Hes1, Sox2
Protein name(s)
MCM2, Nestin
Protein tag(s)
mCherry, tdTomato

Datatype
-
Molecular Function (MF)
-
Biological Process (BP)
gene expression, regulation of gene expression
Cellular Component (CC)
-
Biological Imaging Method
time lapse microscopy, fluorescence microscopy
X scale
NA, 0.8302658 micrometer/pixel
Y scale
NA, 0.8302658 micrometer/pixel
Z scale
2 micrometer/slice, NA
T scale
NA, 30 minutes per time interval, 5 minutes per time interval, 15 minutes per time interval, 20 minutes per time interval

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Risa Sueda, Itaru Imayoshi, Yukiko Harima, Ryoichiro Kageyama (2019) High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain., Genes & development, Volume 33, Number 9-10, pp. 511-523

Published in 2019 May 1 (Electronic publication in March 12, 2019, midnight )

(Abstract) Somatic stem/progenitor cells are active in embryonic tissues but quiescent in many adult tissues. The detailed mechanisms that regulate active versus quiescent stem cell states are largely unknown. In active neural stem cells, Hes1 expression oscillates and drives cyclic expression of the proneural gene Ascl1, which activates cell proliferation. Here, we found that in quiescent neural stem cells in the adult mouse brain, Hes1 levels are oscillatory, although the peaks and troughs are higher than those in active neural stem cells, causing Ascl1 expression to be continuously suppressed. Inactivation of Hes1 and its related genes up-regulates Ascl1 expression and increases neurogenesis. This causes rapid depletion of neural stem cells and premature termination of neurogenesis. Conversely, sustained Hes1 expression represses Ascl1, inhibits neurogenesis, and maintains quiescent neural stem cells. In contrast, induction of Ascl1 oscillations activates neural stem cells and increases neurogenesis in the adult mouse brain. Thus, Ascl1 oscillations, which normally depend on Hes1 oscillations, regulate the active state, while high Hes1 expression and resultant Ascl1 suppression promote quiescence in neural stem cells.
(MeSH Terms)

Contact
Ryoichiro Kageyama, Itaru Imayoshi , Kyoto University, Kyoto University , Institute for Frontier Life and Medical Sciences, Institute for Frontier Life and Medical Sciences
Contributors


Dataset List of 196-Sueda-GeneExpReg

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
Download BDML
Download Images
# 7504
Dataset Kind Image data
Dataset Size 28.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7505
Dataset Kind Image data
Dataset Size 24.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7506
Dataset Kind Image data
Dataset Size 32.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7507
Dataset Kind Image data
Dataset Size 24.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7508
Dataset Kind Image data
Dataset Size 24.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7509
Dataset Kind Image data
Dataset Size 22.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7510
Dataset Kind Image data
Dataset Size 24.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7511
Dataset Kind Image data
Dataset Size 11.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7512
Dataset Kind Image data
Dataset Size 24.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7513
Dataset Kind Image data
Dataset Size 28.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7514
Dataset Kind Image data
Dataset Size 26.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7515
Dataset Kind Image data
Dataset Size 32.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7516
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7517
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7518
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7519
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7520
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7521
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7522
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7523
Datast ID Figure1K_Hes1-svz
Dataset Kind Image data
Dataset Size 43.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7524
Datast ID Figure1L_Hes1-dg
Dataset Kind Image data
Dataset Size 337.2 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7525
Datast ID Figure1M_Ascl1-svz
Dataset Kind Image data
Dataset Size 88.6 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7526
Datast ID Figure1N_Ascl1-dg
Dataset Kind Image data
Dataset Size 114.8 MB
4D view
SSBD:OMERO
Download BDML
Download Image data

# 7527
Dataset Kind Image data
Dataset Size 1.2 GB
4D view
SSBD:OMERO
Download BDML
Download Image data