Summary of 210-Takeo-HFregeneration

SSBD:database
SSBD:database URL
Title
Images of hair follicle regneration from adult mouse cells.
Description
-
Relase date
2022-11-23
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
8 ( Image datasets: 8, Quantitative data datasets: 0 )
Size of Datasets
377.2 MB ( Image datasets: 377.2 MB, Quantitative data datasets: 0 bytes )

Organism(s)
Mus musculus
Gene symbol(s)
NA
Protein name(s)
NA

Datatype
-
Molecular Function (MF)
Biological Process (BP)
hair follicle development
Cellular Component (CC)
Biological Imaging Method
confocal microscopy
X scale
0.3132264 micrometer/pixel, 2.573 micrometer/pixel
Y scale
0.3132264 micrometer/pixel, 2.573 micrometer/pixel
Z scale
-
T scale
-

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Makoto Takeo, Kyosuke Asakawa, Koh-Ei Toyoshima, Miho Ogawa, JingJing Tong, Tarou Irie, Masayuki Yanagisawa, Akio Sato, Takashi Tsuji (2021) Expansion and characterization of epithelial stem cells with potential for cyclical hair regeneration., Scientific reports, Volume 11, Number 1, pp. 1173

Published in 2021 Feb 10 (Electronic publication in Feb. 10, 2021, midnight )

(Abstract) In mammals, organ induction occurs only during embryonic development except for hair follicles (HFs). However, HF-resident epithelial stem cells (HFSCs), which are responsible for repetitive HF regeneration, are not fully characterized. Here, we establish in vitro culture systems that are capable of controlling the ability of HFSCs to regenerate HFs. Based on a method that precisely controlled the number of HFs for regeneration, functional analysis revealed that CD34/CD49f/integrin beta5 (Itgbeta5)-triple-positive (CD34+/CD49f+/Itgbeta5+) cells have multipotency and functional significance for continual hair regeneration. In native HFs, these cells reside in the uppermost area of the bulge region, which is surrounded by tenascin in mice and humans. This study unveils the subpopulation of HFSCs responsible for long-term hair cycling of HFs regenerated from bioengineered HF germ, suggesting the presence of functional heterogeneity among bulge HFSCs and the utility of our culture system to achieve HF regenerative therapy.
(MeSH Terms)

Contact
Takashi Tsuji , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Organ Regeneration
Contributors


Dataset List of 210-Takeo-HFregeneration

#
Dataset ID
Kind
Size
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SSBD:OMERO
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# 7733
Dataset Kind Image data
Dataset Size 2.8 MB
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SSBD:OMERO
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# 7734
Dataset Kind Image data
Dataset Size 2.8 MB
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SSBD:OMERO
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# 7735
Dataset Kind Image data
Dataset Size 2.8 MB
4D view
SSBD:OMERO
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# 7736
Dataset Kind Image data
Dataset Size 2.8 MB
4D view
SSBD:OMERO
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# 7737
Dataset Kind Image data
Dataset Size 99.8 MB
4D view
SSBD:OMERO
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# 7738
Dataset Kind Image data
Dataset Size 99.8 MB
4D view
SSBD:OMERO
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# 7739
Datast ID Fig4c_Itgb5-HF
Dataset Kind Image data
Dataset Size 83.2 MB
4D view
SSBD:OMERO
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# 7740
Dataset Kind Image data
Dataset Size 83.2 MB
4D view
SSBD:OMERO
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