SSBD:database v3

369-Moriyama-deuterateRaman

OMERO gallery,

OMERO index

Project

Title

Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q

Description

All aromatic C–H bonds of triphenylphosphine (PPh3) were efficiently replaced by C–D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D2O, an inexpensive deuterium source. Furthermore, non-radioactive and safe deuterium-incorporated Mito-Q (drug candidate) was prepared from deuterated PPh3 and used for the live-cell Raman imaging to evaluate the mitochondrial uptake.

License

CC BY

Released at

Oct. 20, 2025, midnight

Updated at

Funding

This study was partially supported by JSPS (MEXT grant in aid-for transformative research areas (B) Deuterium Science) KAKENHI Grant Number 20H05738 (for Y.S.), and Life Science and Drug Discovery (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number 23ama121054 (for Y.S.).

# of image datasets

3

Papers

Papers

Paper information: Moriyama S, Mae M, Shibata D, Yamakoshi H, Kajimoto S, Nakabayashi T, Ishimoto T, Mogi K, Sajiki H, Akai S, Sawama Y. Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q. Chem Commun (Camb). 2023 Oct 10;59(81):12100-12103.,
Pubmed ID: 37721453,
DOI: https://doi.org/10.1039/d3cc04410f,
URL: https://pubmed.ncbi.nlm.nih.gov/37721453/

Contacts

Contacts

Yoshinari Sawama (Contact) , Graduate School of Pharmaceutical Sciences , Osaka University
Shogo Moriyama (Imaging Contributor)
Daiki Shibata (Imaging Contributor)
Hiroyuki Yamakoshi (Imaging Contributor)
Shinji Kajimoto (Imaging Contributor)
Takakazu Nakabayashi (Imaging Contributor)

Biosamples

Organisms

Homo sapiens (NCBI:txid9606)

Strains

Cells

Cell lines

HeLa Cell

Ontologies

UBERON