A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The
water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols in vitro and in vivo.
See details in Nagita, et. al. (2024) Chem Commun (Camb).
Kohei Nogita, Takaya Sugahara, Koji Miki, Huiying Mu, Minoru Kobayashi, Hiroshi Harada, Kouichi Ohe (2024) A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent., Chemical communications (Cambridge, England)
Published in 2024 Jan 15 (Electronic publication in Jan. 15, 2024, midnight )
(Abstract) A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols in vitro and in vivo.