PTPdelta/Ptprd promotes the extension of climbing fiber (CF) synaptic territory along Purkinje cell (PC) dendrites predominantly in Aldoc-negative (–) PCs. Gross morphology of the cerebellar vermis with immunofluorescence for the PC marker Calbindin (Calb) and the CF terminal marker VGluT2 in a WT and a PTPdelta KO mouse. Confocal images of the cerebellum showing immunoreactivities of Car8, Aldoc, and VGluT2 in WT and PTPdelta KO mice.
See details in Okuno et. al. (2023) Front Mol Neurosci.