Summary of ssbd-repos-000357

Name
URL
DOI

Title
High-dimensional single-cell phenotyping of yeast heterozygous diploid strains
Description

Image and morphological data for high-dimensional single-cell phenotyping of yeast heterozygous diploid strains

Submited Date
2024-05-16
Release Date
2024-07-12
Updated Date
-
License
Funding information
Grants-in-Aid of Research Activity Start- up https://www.jsps.go.jp/english/ (grant number JP26882019) to S.O. Grants-in-Aid of Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan http://www.mext.go.jp/en/ (grant number 24370002 and 15H04402) to Y.O.
File formats
jpg, tsv, txt, xls, xlsx
Data size
10.0 GB

Organism
Saccharomyces cerevisiae (NCBI:txid:4932)
Strain
BY4743
Cell Line
-
Genes
YAL001C, YAL003W, YAL025C, YAL032C, YAL033W, YAL034C-B, YAL034W-A, YAL038W, YAL041W, YAL043C, YAR007C, YAR008W, YAR019C, YBL004W, YBL014C, YBL018C, YBL020W, YBL023C, YBL026W, YBL030C, YBL034C, YBL035C, YBL040C, YBL041W, YBL050W, YBL073W, YBL074C, YBL076C, YBL077W, YBL084C, YBL092W, YBL097W, YBL105C, YBR002C, YBR004C, YBR011C, YBR017C, YBR029C, YBR038W, YBR039W, YBR049C, YBR055C, YBR060C, YBR070C, YBR079C, YBR080C, YBR086C, YBR087W, YBR088C, YBR089W, YBR091C, YBR096W, YBR102C, YBR109C, YBR110W, YBR117C, YBR118W, YBR121C, YBR123C, YBR124W, YBR135W, YBR136W, YBR140C, YBR142W, YBR143C, YBR152W, YBR153W, YBR154C, YBR155W, YBR160W, YBR167C, YBR190W, YBR192W, YBR193C, YBR196C, YBR198C, YBR202W, YBR211C, YBR234C, YBR236C, YBR237W, YBR243C, YBR247C, YBR252W, YBR253W, YBR254C, YBR256C, YBR257W, YBR265W, YCL004W, YCL017C, YCL031C, YCL041C, YCL043C, YCL052C, YCL054W, YCL059C, YCR012W, YCR013C, YCR035C, YCR052W, YCR054C, YCR057C, YCR072C, YCR093W, YDL003W, YDL004W, YDL007W, YDL008W, YDL014W, YDL015C, YDL016C, YDL017W, YDL028C, YDL029W, YDL030W, YDL031W, YDL043C, YDL045C, YDL055C, YDL058W, YDL060W, YDL064W, YDL084W, YDL087C, YDL092W, YDL097C, YDL098C, YDL102W, YDL103C, YDL105W, YDL108W, YDL111C, YDL120W, YDL126C, YDL132W, YDL139C, YDL140C, YDL141W, YDL143W, YDL145C, YDL147W, YDL148C, YDL150W, YDL152W, YDL153C, YDL158C, YDL163W, YDL164C, YDL165W, YDL166C, YDL193W, YDL195W, YDL196W, YDL205C, YDL207W, YDL208W, YDL209C, YDL212W, YDL217C, YDL220C, YDL221W, YDL235C, YDR002W, YDR013W, YDR016C, YDR021W, YDR023W, YDR037W, YDR041W, YDR044W, YDR045C, YDR047W, YDR050C, YDR052C, YDR053W, YDR054C, YDR060W, YDR062W, YDR064W, YDR081C, YDR082W, YDR086C, YDR087C, YDR088C, YDR091C, YDR113C, YDR118W, YDR141C, YDR145W, YDR160W, YDR164C, YDR166C, YDR167W, YDR168W, YDR170C, YDR172W, YDR177W, YDR180W, YDR182W, YDR187C, YDR188W, YDR189W, YDR190C, YDR196C, YDR201W, YDR208W, YDR211W, YDR212W, YDR224C, YDR228C, YDR232W, YDR235W, YDR236C, YDR238C, YDR240C, YDR243C, YDR246W, YDR267C, YDR280W, YDR288W, YDR292C, YDR299W, YDR301W, YDR302W, YDR303C, YDR308C, YDR311W, YDR324C, YDR325W, YDR327W, YDR328C, YDR331W, YDR339C, YDR341C, YDR353W, YDR355C, YDR356W, YDR361C, YDR362C, YDR365C, YDR367W, YDR373W, YDR376W, YDR381W, YDR390C, YDR394W, YDR396W, YDR397C, YDR398W, YDR404C, YDR407C, YDR412W, YDR413C, YDR416W, YDR427W, YDR429C, YDR434W, YDR437W, YDR449C, YDR454C, YDR460W, YDR464W, YDR468C, YDR472W, YDR473C, YDR478W, YDR483W, YDR487C, YDR489W, YDR498C, YDR499W, YDR510W, YDR526C, YDR527W, YDR531W, YEL002C, YEL019C, YEL026W, YEL032W, YEL034W, YEL035C, YEL055C, YEL058W, YER003C, YER006W, YER008C, YER009W, YER012W, YER013W, YER018C, YER021W, YER022W, YER023W, YER025W, YER036C, YER038C, YER043C, YER048W-A, YER082C, YER093C, YER094C, YER104W, YER112W, YER125W, YER126C, YER127W, YER133W, YER136W, YER146W, YER147C, YER148W, YER157W, YER159C, YER165W, YER168C, YER171W, YER172C, YFL002C, YFL005W, YFL008W, YFL009W, YFL017C, YFL017W-A, YFL022C, YFL024C, YFL029C, YFL034C-B, YFL037W, YFL038C, YFL039C, YFL045C, YFR002W, YFR003C, YFR004W, YFR005C, YFR027W, YFR028C, YFR029W, YFR031C, YFR037C, YFR042W, YFR050C, YFR051C, YFR052W, YGL001C, YGL008C, YGL011C, YGL018C, YGL022W, YGL030W, YGL040C, YGL044C, YGL047W, YGL048C, YGL055W, YGL061C, YGL065C, YGL068W, YGL069C, YGL073W, YGL074C, YGL075C, YGL091C, YGL092W, YGL093W, YGL097W, YGL098W, YGL099W, YGL102C, YGL103W, YGL111W, YGL112C, YGL113W, YGL116W, YGL120C, YGL122C, YGL123W, YGL128C, YGL130W, YGL137W, YGL142C, YGL145W, YGL150C, YGL155W, YGL169W, YGL171W, YGL172W, YGL201C, YGL207W, YGL225W, YGL233W, YGL238W, YGL239C, YGL245W, YGL247W, YGR002C, YGR005C, YGR009C, YGR013W, YGR024C, YGR029W, YGR030C, YGR046W, YGR047C, YGR048W, YGR060W, YGR065C, YGR073C, YGR074W, YGR075C, YGR082W, YGR083C, YGR090W, YGR091W, YGR094W, YGR095C, YGR098C, YGR099W, YGR103W, YGR113W, YGR114C, YGR115C, YGR116W, YGR119C, YGR120C, YGR128C, YGR140W, YGR145W, YGR147C, YGR156W, YGR158C, YGR172C, YGR175C, YGR179C, YGR185C, YGR186W, YGR190C, YGR191W, YGR195W, YGR198W, YGR211W, YGR216C, YGR218W, YGR245C, YGR246C, YGR251W, YGR253C, YGR264C, YGR265W, YGR267C, YGR274C, YGR277C, YGR278W, YGR280C, YHL015W, YHR005C-A, YHR007C, YHR019C, YHR020W, YHR023W, YHR024C, YHR036W, YHR040W, YHR042W, YHR058C, YHR062C, YHR065C, YHR068W, YHR069C, YHR070W, YHR072W, YHR074W, YHR083W, YHR085W, YHR088W, YHR101C, YHR107C, YHR118C, YHR122W, YHR143W-A, YHR148W, YHR164C, YHR166C, YHR170W, YHR172W, YHR186C, YHR188C, YHR190W, YHR196W, YHR197W, YIL003W, YIL004C, YIL019W, YIL021W, YIL022W, YIL026C, YIL031W, YIL046W, YIL048W, YIL051C, YIL061C, YIL062C, YIL063C, YIL068C, YIL075C, YIL078W, YIL083C, YIL091C, YIL104C, YIL106W, YIL109C, YIL115C, YIL118W, YIL126W, YIL129C, YIL142W, YIL143C, YIL144W, YIL147C, YIL150C, YIL171W, YIR006C, YIR008C, YIR010W, YIR011C, YIR012W, YIR015W, YIR022W, YJL001W, YJL002C, YJL005W, YJL008C, YJL009W, YJL010C, YJL011C, YJL014W, YJL015C, YJL019W, YJL025W, YJL026W, YJL031C, YJL032W, YJL033W, YJL034W, YJL035C, YJL039C, YJL041W, YJL050W, YJL054W, YJL061W, YJL069C, YJL072C, YJL074C, YJL076W, YJL081C, YJL085W, YJL086C, YJL087C, YJL090C, YJL091C, YJL097W, YJL104W, YJL109C, YJL111W, YJL125C, YJL143W, YJL156C, YJL167W, YJL173C, YJL174W, YJL194W, YJL195C, YJL202C, YJL203W, YJR002W, YJR006W, YJR007W, YJR012C, YJR013W, YJR016C, YJR017C, YJR022W, YJR023C, YJR041C, YJR042W, YJR045C, YJR046W, YJR057W, YJR064W, YJR065C, YJR067C, YJR068W, YJR072C, YJR076C, YJR093C, YJR112W, YJR123W, YJR141W, YKL004W, YKL006C-A, YKL012W, YKL013C, YKL014C, YKL018W, YKL019W, YKL021C, YKL022C, YKL024C, YKL028W, YKL033W, YKL035W, YKL036C, YKL042W, YKL045W, YKL049C, YKL052C, YKL058W, YKL059C, YKL060C, YKL078W, YKL082C, YKL083W, YKL088W, YKL089W, YKL095W, YKL099C, YKL104C, YKL108W, YKL111C, YKL112W, YKL122C, YKL125W, YKL141W, YKL144C, YKL145W, YKL152C, YKL153W, YKL154W, YKL165C, YKL172W, YKL173W, YKL180W, YKL182W, YKL186C, YKL189W, YKL192C, YKL193C, YKL195W, YKL196C, YKL203C, YKL210W, YKR002W, YKR004C, YKR008W, YKR022C, YKR025W, YKR037C, YKR038C, YKR062W, YKR063C, YKR068C, YKR071C, YKR079C, YKR081C, YKR083C, YKR086W, YLL003W, YLL004W, YLL008W, YLL011W, YLL018C, YLL031C, YLL034C, YLL035W, YLL036C, YLL037W, YLL050C, YLR002C, YLR005W, YLR007W, YLR008C, YLR009W, YLR010C, YLR022C, YLR026C, YLR029C, YLR033W, YLR045C, YLR051C, YLR060W, YLR066W, YLR071C, YLR075W, YLR076C, YLR078C, YLR086W, YLR088W, YLR100W, YLR101C, YLR103C, YLR105C, YLR106C, YLR115W, YLR116W, YLR117C, YLR127C, YLR129W, YLR131C, YLR132C, YLR140W, YLR141W, YLR145W, YLR147C, YLR153C, YLR163C, YLR166C, YLR167W, YLR175W, YLR186W, YLR195C, YLR196W, YLR197W, YLR198C, YLR208W, YLR212C, YLR215C, YLR222C, YLR223C, YLR229C, YLR230W, YLR243W, YLR249W, YLR259C, YLR272C, YLR274W, YLR275W, YLR276C, YLR277C, YLR291C, YLR293C, YLR298C, YLR305C, YLR310C, YLR314C, YLR316C, YLR317W, YLR321C, YLR323C, YLR336C, YLR339C, YLR340W, YLR347C, YLR355C, YLR359W, YLR378C, YLR379W, YLR397C, YLR409C, YLR424W, YLR430W, YLR438C-A, YLR440C, YLR457C, YLR458W, YLR459W, YML010W, YML015C, YML023C, YML025C, YML031W, YML043C, YML046W, YML049C, YML064C, YML065W, YML069W, YML077W, YML085C, YML092C, YML093W, YML098W, YML105C, YML114C, YML125C, YML126C, YML127W, YML130C, YMR001C, YMR005W, YMR013C, YMR028W, YMR033W, YMR043W, YMR047C, YMR049C, YMR059W, YMR061W, YMR076C, YMR079W, YMR093W, YMR094W, YMR108W, YMR112C, YMR113W, YMR117C, YMR128W, YMR131C, YMR134W, YMR146C, YMR149W, YMR168C, YMR185W, YMR197C, YMR200W, YMR203W, YMR208W, YMR211W, YMR213W, YMR218C, YMR220W, YMR227C, YMR229C, YMR235C, YMR236W, YMR239C, YMR240C, YMR260C, YMR268C, YMR270C, YMR277W, YMR281W, YMR288W, YMR290C, YMR290W-A, YMR296C, YMR298W, YMR301C, YMR308C, YMR309C, YMR314W, YNL002C, YNL006W, YNL007C, YNL026W, YNL038W, YNL039W, YNL061W, YNL062C, YNL075W, YNL088W, YNL102W, YNL103W, YNL110C, YNL112W, YNL113W, YNL114C, YNL118C, YNL124W, YNL126W, YNL131W, YNL132W, YNL137C, YNL149C, YNL150W, YNL151C, YNL152W, YNL158W, YNL161W, YNL162W, YNL163C, YNL172W, YNL178W, YNL181W, YNL182C, YNL188W, YNL189W, YNL207W, YNL216W, YNL221C, YNL222W, YNL232W, YNL240C, YNL244C, YNL245C, YNL247W, YNL251C, YNL256W, YNL258C, YNL260C, YNL261W, YNL262W, YNL263C, YNL267W, YNL272C, YNL282W, YNL287W, YNL290W, YNL306W, YNL308C, YNL310C, YNL312W, YNL313C, YNL317W, YNR003C, YNR011C, YNR016C, YNR017W, YNR026C, YNR035C, YNR038W, YNR043W, YNR046W, YNR053C, YNR054C, YOL005C, YOL010W, YOL021C, YOL022C, YOL026C, YOL034W, YOL038W, YOL040C, YOL066C, YOL069W, YOL077C, YOL078W, YOL094C, YOL097C, YOL102C, YOL120C, YOL123W, YOL127W, YOL130W, YOL133W, YOL134C, YOL135C, YOL139C, YOL144W, YOL146W, YOL149W, YOR004W, YOR020C, YOR046C, YOR048C, YOR056C, YOR057W, YOR060C, YOR063W, YOR074C, YOR075W, YOR077W, YOR095C, YOR098C, YOR102W, YOR103C, YOR110W, YOR116C, YOR117W, YOR119C, YOR122C, YOR143C, YOR145C, YOR146W, YOR148C, YOR149C, YOR151C, YOR157C, YOR159C, YOR160W, YOR168W, YOR169C, YOR174W, YOR176W, YOR181W, YOR194C, YOR203W, YOR204W, YOR206W, YOR207C, YOR210W, YOR217W, YOR218C, YOR224C, YOR232W, YOR236W, YOR244W, YOR249C, YOR250C, YOR254C, YOR256C, YOR257W, YOR259C, YOR260W, YOR261C, YOR262W, YOR272W, YOR278W, YOR281C, YOR282W, YOR287C, YOR294W, YOR310C, YOR319W, YOR326W, YOR329C, YOR335C, YOR336W, YOR340C, YOR341W, YOR353C, YOR361C, YOR362C, YOR370C, YOR372C, YOR373W, YPL007C, YPL010W, YPL011C, YPL012W, YPL016W, YPL020C, YPL028W, YPL043W, YPL044C, YPL063W, YPL075W, YPL076W, YPL082C, YPL083C, YPL085W, YPL093W, YPL094C, YPL117C, YPL122C, YPL124W, YPL126W, YPL128C, YPL131W, YPL142C, YPL143W, YPL146C, YPL151C, YPL153C, YPL160W, YPL169C, YPL175W, YPL190C, YPL204W, YPL209C, YPL210C, YPL211W, YPL217C, YPL218W, YPL228W, YPL231W, YPL233W, YPL235W, YPL237W, YPL238C, YPL242C, YPL243W, YPL251W, YPL252C, YPL255W, YPL266W, YPR010C, YPR016C, YPR019W, YPR025C, YPR033C, YPR034W, YPR035W, YPR041W, YPR048W, YPR055W, YPR056W, YPR082C, YPR085C, YPR086W, YPR088C, YPR094W, YPR103W, YPR104C, YPR105C, YPR107C, YPR108W, YPR110C, YPR112C, YPR113W, YPR133C, YPR136C, YPR137W, YPR142C, YPR143W, YPR144C, YPR161C, YPR162C, YPR165W, YPR168W, YPR169W, YPR175W, YPR176C, YPR177C, YPR178W, YPR180W, YPR181C, YPR182W, YPR183W, YPR186C, YPR187W, YPR190C
Proteins
-

GO Molecular Function (MF)
-
GO Biological Process (BP)
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GO Cellular Component (CC)
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Study Type
-
Imaging Methods
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Method Summary

See details in Ohnuki et. al. (2018) PLoS Biol.

Related paper(s)

Shinsuke Ohnuki, Yoshikazu Ohya (2018) High-dimensional single-cell phenotyping reveals extensive haploinsufficiency., PLoS biology, Volume 16, Number 5, pp. e2005130

Published in 2018 May (Electronic publication in May 16, 2018, midnight )

(Abstract) Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function mutation, has been rarely observed. However, high-dimensional single-cell phenotyping of yeast morphological characteristics revealed haploinsufficiency phenotypes for more than half of 1,112 essential genes under optimal growth conditions. Additionally, 40% of the essential genes with no obvious phenotype under optimal growth conditions displayed haploinsufficiency under severe growth conditions. Haploinsufficiency was detected more frequently in essential genes than in nonessential genes. Similar haploinsufficiency phenotypes were observed mostly in mutants with heterozygous deletion of functionally related genes, suggesting that haploinsufficiency phenotypes were caused by functional defects of the genes. A global view of the gene network was presented based on the similarities of the haploinsufficiency phenotypes. Our dataset contains rich information regarding essential gene functions, providing evidence that single-cell phenotyping is a powerful approach, even in the heterozygous condition, for analyzing complex biological systems.
(MeSH Terms)

Contact(s)
Yoshikazu Ohya
Organization(s)
University of Tokyo , Department of Integrated Biosciences, Graduate School of Frontier Sciences, , Laboratory of Signal Transduction
Image Data Contributors
Quantitative Data Contributors

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