SSBD - CREST-MC Paper - Mashiko D et. al. (2022), Sci Rep 12(1), 9411

Paper information

Daisuke Mashiko, Zenki Ikeda, Mikiko Tokoro, Yu Hatano, Tatsuma Yao, Tetsuya J Kobayashi, Noritaka Fukunaga, Yoshimasa Asada, Kazuo Yamagata (2022) Asynchronous division at 4-8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation., Scientific reports, Volume 12, Number 1, pp. 9411

Electronic Published Date

June 7, 2022, midnight

Published Date

2022 Jun 7

Abstract

To improve the performance of assisted reproductive technology, it is necessary to find an indicator that can identify and select embryos that will be born or be aborted. We searched for indicators of embryo selection by comparing born/abort mouse embryos. We found that asynchronous embryos during the 4-8-cell stage were predisposed to be aborted. In asynchronous mouse embryos, the nuclear translocation of YAP1 in some blastomeres and compaction were delayed, and the number of ICMs was reduced. Hence, it is possible that asynchronous embryos have abnormal differentiation. When the synchrony of human embryos was observed, it was confirmed that embryos that did not reach clinical pregnancy had asynchrony as in mice. This could make synchrony a universal indicator common to all animal species.

MeSH Terms

DOI

doi: 10.1038/s41598-022-13646-8

PubMed Central ID

PMC9174281

SSBD:database

CREST MC: Mashiko D et. al. (2022), Sci Rep 12(1), 9411