Summary of 78-Takagi-CellDyn

SSBD:database
SSBD:database URL
Title
TEM images of the formation of subretinal hyperreflective material and ORTs in the process of pathological changes
Description
-
Relase date
2018-11-14
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
8 ( Image datasets: 8, Quantitative data datasets: 0 )
Size of Datasets
6.7 MB ( Image datasets: 6.7 MB, Quantitative data datasets: 0 bytes )

Organism(s)
H. sapiens

Datatype
cell dynamics
Molecular Function (MF)
Biological Process (BP)
retinal pigment epithelium development
Cellular Component (CC)
-
Biological Imaging Method
-
XYZ Scale
X: 0.0090909 micrometer/pixel, Y: 0.0067568 micrometer/pixel, Z: 1 micrometer/slice, XY: 0.0066667 micrometer/pixel, Z: 1 micrometer/slice
T scale
-

Image Acquisition
Experiment type
Electrophysiology
Microscope type
BrightfieldMicroscope
Acquisition mode
Other
Contrast method
Other
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Seiji Takagi, Michiko Mandai, Noriko Miyamoto, Akihiro Nishida, Yasuhiko Hirami, Hirofumi Uyama, Midori Yamamoto, Masayo Takahashi, Goji Tomita, Yasuo Kurimoto (2017) Incidence of outer retinal tubulation in eyes with choroidal neovascularization under intravitreal anti-vascular endothelial growth factor therapy in a Japanese population., Clinical ophthalmology (Auckland, N.Z.), Volume 11, pp. 1219-1225

Published in 2017 (Electronic publication in June 28, 2017, midnight )

(Abstract) PURPOSE: The purpose of this study was to investigate the occurrence of outer retinal tubulation (ORT) among patients with different types of choroidal neovascularization (CNV) over time. MATERIALS AND METHODS: In this retrospective chart review, disease type was classified as typical age-related macular degeneration (t-AMD), polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), or myopic CNV (mCNV). Spectral domain-optical coherence tomography (SD-OCT) images were evaluated for the appearance of ORT and subretinal fibrosis and fluid. Furthermore, the association of the presence of ORT with clinical data and OCT findings was investigated. RESULTS: Among the 136 eyes studied, the overall rates of occurrence of ORT were 7.8%, 18.8%, and 31.6% after 12, 24, and 36 months from baseline, respectively. Among patients with t-AMD, RAP, and mCNV, the occurrence of ORT increased soon after the initial visit. In contrast, among patients with PCV, the occurrence of ORT increased slowly over time. Patients with and without ORT - ORT(+) and ORT(-) groups, respectively - differed significantly in terms of sex ratio and presence of intraretinal fluid at the initial visit and presence of subretinal fibrosis at 3 years from baseline. The ORT(+) group exhibited lower visual acuity (VA; 0.67+/-0.43) than that of the ORT(-) group (0.41+/-0.36; P<0.001). CONCLUSION: The occurrence of ORT tended to increase more slowly among eyes diagnosed with PCV than among eyes with other types of CNV.

Contact
Seiji Takagi , Kobe City Medical Center general hospital , Department of Ophthalmology
Contributors
Seiji Takagi, Michiko Mandai, Noriko Miyamoto, Akihiro Nishida, Yasuhiko Hirami, Hirofumi Uyama, Midori Yamamoto, Masayo Takahashi, Goji Tomita, Yasuo Kurimoto


Dataset List of 78-Takagi-CellDyn

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
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# 4035
Datast ID fig2A_1
Dataset Kind Image data
Dataset Size 541.0 KB
4D view
SSBD:OMERO
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# 4036
Datast ID fig2A_2
Dataset Kind Image data
Dataset Size 890.0 KB
4D view
SSBD:OMERO
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# 4037
Datast ID fig2A_3
Dataset Kind Image data
Dataset Size 1004.8 KB
4D view
SSBD:OMERO
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# 4038
Datast ID fig2A_4
Dataset Kind Image data
Dataset Size 804.1 KB
4D view
SSBD:OMERO
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# 4039
Datast ID fig2B_1
Dataset Kind Image data
Dataset Size 739.6 KB
4D view
SSBD:OMERO
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# 4040
Datast ID fig2B_2
Dataset Kind Image data
Dataset Size 993.7 KB
4D view
SSBD:OMERO
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# 4041
Datast ID fig2B_3
Dataset Kind Image data
Dataset Size 937.0 KB
4D view
SSBD:OMERO
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# 4042
Datast ID fig2B_4
Dataset Kind Image data
Dataset Size 975.5 KB
4D view
SSBD:OMERO
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