Summary of 170-Tsutsui-HookBM

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High-resolution three-dimensional images of the hook basement membrane in mouse dorsal skin.
Relase date
Updated date
Image data based on Experiment
Number of Datasets
1 ( Image datasets: 1, Quantitative data datasets: 0 )
Size of Datasets
236.6 MB ( Image datasets: 236.6 MB, Quantitative data datasets: 0 bytes )

Mus musculus

Molecular Function (MF)
Biological Process (BP)
Cellular Component (CC)
basement membrane
Biological Imaging Method
confocal microscopy
X scale
0.0408118 micrometer/pixel
Y scale
0.0408118 micrometer/pixel
Z scale
0.1804551 micrometer/slice
T scale

Image Acquisition
Experiment type
Microscope type
Acquisition mode
Contrast method
Microscope model
Detector model
Objective model
Filter set

Related paper(s)

Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H Miner, Hironobu Fujiwara (2021) Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions., Nature communications, Volume 12, Number 1, pp. 2577

Published in 2021 May 10 (Electronic publication in May 10, 2021, midnight )

(Abstract) Inter-tissue interaction is fundamental to multicellularity. Although the basement membrane (BM) is located at tissue interfaces, its mode of action in inter-tissue interactions remains poorly understood, mainly because the molecular and structural details of the BM at distinct inter-tissue interfaces remain unclear. By combining quantitative transcriptomics and immunohistochemistry, we systematically identify the cellular origin, molecular identity and tissue distribution of extracellular matrix molecules in mouse hair follicles, and reveal that BM composition and architecture are exquisitely specialized for distinct inter-tissue interactions, including epithelial-fibroblast, epithelial-muscle and epithelial-nerve interactions. The epithelial-fibroblast interface, namely, hair germ-dermal papilla interface, makes asymmetrically organized side-specific heterogeneity in the BM, defined by the newly characterized interface, hook and mesh BMs. One component of these BMs, laminin alpha5, is required for hair cycle regulation and hair germ-dermal papilla anchoring. Our study highlights the significance of BM heterogeneity in distinct inter-tissue interactions.
(MeSH Terms)

Hironobu Fujiwara , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Tissue Microenvironment

Dataset List of 170-Tsutsui-HookBM

Dataset ID
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# 6847
Datast ID Airyscan_hook_BM
Dataset Kind Image data
Dataset Size 236.6 MB
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