Summary of 116-Yamada-Glycogen

SSBD:database
SSBD:database URL
Title
Immunostaining images of Glycogen in the fat body or body wall muscles in Drosophila
Description
-
Relase date
2019-11-20
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
12 ( Image datasets: 12, Quantitative data datasets: 0 )
Size of Datasets
67.3 MB ( Image datasets: 67.3 MB, Quantitative data datasets: 0 bytes )

Organism(s)
Drosophila

Datatype
tissuel immunostaining
Molecular Function (MF)
Biological Process (BP)
glycogen breakdown
Cellular Component (CC)
cell
Biological Imaging Method
-
XYZ Scale
-
T scale
-

Image Acquisition
Experiment type
Immunofluorescence
Microscope type
ConfocalMicroscope
Acquisition mode
Other
Contrast method
Fluorescence
Microscope model
Zeiss LSM700
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura (2018) Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila., Development (Cambridge, England), Volume 145, Number 6

Published in 2018 Mar 14 (Electronic publication in March 14, 2018, midnight )

(Abstract) Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the major role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear. Here, we show that glycogen metabolism is regulated in a tissue-specific manner under starvation conditions in the fruit fly Drosophila The mobilization of fat body glycogen in larvae is independent of Adipokinetic hormone (Akh, the glucagon homolog) but is regulated by sugar availability in a tissue-autonomous manner. Fat body glycogen plays a crucial role in the maintenance of circulating sugars, including trehalose, under fasting conditions. These results demonstrate the importance of fat body glycogen as a metabolic safeguard in Drosophila.
(MeSH Terms)

Contact
Takashi Nishimura , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Growth Control Signaling
Contributors
Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura


Dataset List of 116-Yamada-Glycogen

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
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# 4679
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
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# 4680
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
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# 4681
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
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# 4682
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4683
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4684
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4685
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4686
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4687
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4688
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4689
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
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# 4690
Dataset Kind Image data
Dataset Size 5.6 MB
4D view
SSBD:OMERO
Download BDML
Download Image data