Detail of ct_Mmu_PSM



Project
Title
Hes7 reporter expression dynamics in the presomitic mesoderm (PSM) of M. musculus control embryo
Description
NA
Release, Updated
2016-01-18,
2018-11-15
License
CC BY-NC-SA
Kind
Image data based on Experiment related Quantitative data ; ct_Mmu_PSM
File Formats
Data size
217.0 KB

Organism
M. musculus ( NCBI:txid10090 )
Strain(s)
-
Cell Line
-
Gene symbols
Hes7

Datatype
gene expression data
Molecular Function (MF)
Biological Process (BP)
-
Cellular Component (CC)
-
Biological Imaging Method
XYZ Scale
-
T scale
5 minute for each time interval

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Summary of Methods
See details in Harima et al. (2013) Cell Reports, 3(1): 1-7
Related paper(s)

Yukiko Harima, Yoshiki Takashima, Yuriko Ueda, Toshiyuki Ohtsuka, Ryoichiro Kageyama (2013) Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene., Cell reports, Volume 3, Number 1, pp. 1-7

Published in 2013 Jan 31 (Electronic publication in Dec. 7, 2012, midnight )

(Abstract) Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing. The mechanism that regulates the pace of segmentation remains to be determined, but mathematical modeling has predicted that negative feedback with shorter delays would give rise to dampened but more rapid oscillations. Here, we show that reducing the number of introns within the Hes7 gene shortens the delay and results in a more rapid tempo of both Hes7 oscillation and somite segmentation, increasing the number of somites and vertebrae in the cervical and upper thoracic region. These results suggest that the number of introns is important for the appropriate tempo of oscillatory expression and that Hes7 is a key regulator of the pace of the segmentation clock.
(MeSH Terms)

Contact
Ryoichiro Kageyama , Kyoto University , Institute for Virus Research , Kageyama Laboratory
Contributors
Yukiko Harima, Yoshiki Takashima, Yuriko Ueda, Toshiyuki Ohtsuka, and Ryoichiro Kageyama

OMERO Dataset
OMERO Project
Source