Detail of Fig1f_HE_humanskin



Project
Title
HE staining image of human skin.
Description
HE staining image of human skin.
Release, Updated
2022-11-23
License
CC BY
Kind
Image data
File Formats
.czi
Data size
323.4 MB

Organism
Homo sapiens ( NCBI:txid9606 )
Strain(s)
-
Cell Line
-

Datatype
-
Molecular Function (MF)
Biological Process (BP)
skin epidermis development ( GO:0098773 )
Cellular Component (CC)
Biological Imaging Method
confocal microscopy ( Fbbi:00000251 )
X scale
0.2194382 micrometer/pixel
Y scale
0.2194382 micrometer/pixel
Z scale
-
T scale
-

Image Acquisition
Experiment type
-
Microscope type
-
Acquisition mode
-
Contrast method
-
Microscope model
-
Detector model
-
Objective model
-
Filter set
-

Summary of Methods
See details in Kimura S, et. al. (2020) Commun Biol., 3(1):637.
Related paper(s)

Shun Kimura, Ayako Tsuchiya, Miho Ogawa, Miki Ono, Nao Suda, Kaori Sekimoto, Makoto Takeo, Takashi Tsuji (2020) Tissue-scale tensional homeostasis in skin regulates structure and physiological function., Communications biology, Volume 3, Number 1, pp. 637

Published in 2020 Oct 30 (Electronic publication in Oct. 30, 2020, midnight )

(Abstract) Tensional homeostasis is crucial for organ and tissue development, including the establishment of morphological and functional properties. Skin plays essential roles in waterproofing, cushioning and protecting deeper tissues by forming internal tension-distribution patterns, which involves aligning various cells, appendages and extracellular matrices (ECMs). The balance of traction force is thought to contribute to the formation of strong and pliable physical structures that maintain their integrity and flexibility. Here, by using a human skin equivalent (HSE), the horizontal tension-force balance of the dermal layer was found to clearly improve HSE characteristics, such as the physical relationship between cells and the ECM. The tension also promoted skin homeostasis through the activation of mechano-sensitive molecules such as ROCK and MRTF-A, and these results compared favourably to what was observed in tension-released models. Tension-induced HSE will contribute to analyze skin physiological functions regulated by tensional homeostasis as an alternative animal model.
(MeSH Terms)

Contact
Takashi Tsuji , RIKEN , Center for Biosystems Dynamics Research , Laboratory for Organ Regeneration
Contributors

OMERO Dataset
OMERO Project
Source