Detail of fig2a_osseoImplant
Project
Title
SEM image of the engrafted osseo-integrated implant tooth at 30 days post transplantation
Description
NA
Release, Updated
2019-11-20
License
CC BY
Kind
Image data
based on Experiment
File Formats
Data size
1020.0 KB
Datatype
tissue structure
Molecular Function (MF)
Biological Process (BP)
cementum mineralization
(
GO:0071529
)
Cellular Component (CC)
-
Biological Imaging Method
XYZ Scale
XY: 0.119 micrometer/pixel, Z: NA
T scale
-
Image Acquisition
Experiment type
Other
Microscope type
Other
Acquisition mode
BrightField
Contrast method
Brightfield
Microscope model
-
Detector model
-
Objective model
-
Filter set
-
Summary of Methods
See details in Oshima et al. (2014) Sci Rep, 4: 6044.
Related paper(s)
Masamitsu Oshima, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki, Tomohide Isobe, Ayaka Sugawara, Miho Ogawa, Chie Tanaka, Masahiro Saito, Shohei Kasugai, Teruko Takano-Yamamoto, Takashi Inoue, Katsunari Tezuka, Takuo Kuboki, Akira Yamaguchi, Takashi Tsuji (2014) Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy., Scientific reports, Volume 4, pp. 6044
Published in 2014 Aug 13 (Electronic publication in Aug. 13, 2014, midnight )
- doi: 10.1038/srep06044
-
pmid: 25116435
(Abstract) Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.(MeSH Terms)
- Animals
- Artificial Organs[major]
- Biocompatible Materials
- Bone Regeneration
- Cell Adhesion Molecules/biosynthesis
- Dental Cementum/metabolism
- Dental Implants[major]
- Dental Sac/cytology
- Dental Sac/physiology
- Durapatite/chemistry
- Extracellular Matrix Proteins/biosynthesis
- Gene Expression Regulation
- Immunohistochemistry
- Mice
- Mice, Inbred C57BL
- Orthodontics, Corrective/methods[major]
- Osteocalcin/biosynthesis
- Periodontal Ligament/physiology
- Periodontal Ligament/surgery
- Tissue Engineering/methods[major]
- Tooth/surgery
- Tooth/transplantation[major]
Contact
Takashi Tsuji
, Tokyo University of Science
, Research Institute for Science and Technology
Contributors
Masamitsu Oshima, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki, Tomohide Isobe, Ayaka Sugawara, Miho Ogawa, Chie Tanaka, Masahiro Saito, Shohei Kasugai, Teruko Takano-Yamamoto, Takashi Inoue, Katsunari Tezuka, Takuo Kuboki, Akira Yamaguchi, Takashi Tsuji
OMERO Dataset
OMERO Project
Source