Summary of 103-Hirayama-GlandReg

SSBD:database
SSBD:database URL
Title
Phase images of the development of natural and bioengineered lacrimal gland germ and harderian gland germ in time schedule
Description
-
Relase date
2019-11-20
Updated date
-
License
CC BY
Kind
Image data based on Experiment
Number of Datasets
24 ( Image datasets: 24, Quantitative data datasets: 0 )
Size of Datasets
34.3 MB ( Image datasets: 34.3 MB, Quantitative data datasets: 0 bytes )

Organism(s)
M. musculus
Gene symbol(s)
NA
Protein name(s)
NA

Datatype
gland regeneration
Molecular Function (MF)
Biological Process (BP)
harderian gland development, lacrimal gland development
Cellular Component (CC)
-
Biological Imaging Method
-
XYZ Scale
XY: 1.290 micrometer/pixel, Z: NA
T scale
1 day for each time interval

Image Acquisition
Experiment type
Other
Microscope type
Other
Acquisition mode
BrightField
Contrast method
Phase
Microscope model
Carl Zeiss Axioimager A1
Detector model
-
Objective model
-
Filter set
-

Related paper(s)

Masatoshi Hirayama, Miho Ogawa, Masamitsu Oshima, Yurie Sekine, Kentaro Ishida, Kentaro Yamashita, Kazutaka Ikeda, Shigeto Shimmura, Tetsuya Kawakita, Kazuo Tsubota, Takashi Tsuji (2013) Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ., Nature communications, Volume 4, pp. 2497

Published in 2013

(Abstract) The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic transplantation of bioengineered lacrimal gland germs into adult mice with an extra-orbital lacrimal gland defect, a mouse model that mimics the corneal epithelial damage caused by lacrimal gland dysfunction. The bioengineered lacrimal gland germs and harderian gland germs both develop in vivo and achieve sufficient physiological functionality, including tear production in response to nervous stimulation and ocular surface protection. This study demonstrates the potential for bioengineered organ replacement to functionally restore the lacrimal gland.
(MeSH Terms)

Contact
Takashi Tsuji , Tokyo University of Science, , Research Institute for Science and Technology
Contributors
Masatoshi Hirayama, Miho Ogawa, Masamitsu Oshima, Yurie Sekine, Kentaro Ishida, Kentaro Yamashita, Kazutaka Ikeda, Shigeto Shimmura, Tetsuya Kawakita, Kazuo Tsubota, Takashi Tsuji


Dataset List of 103-Hirayama-GlandReg

#
Dataset ID
Kind
Size
4D View
SSBD:OMERO
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Download Images
# 4367
Dataset Kind Image data
Dataset Size 1.3 MB
4D view
SSBD:OMERO
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# 4368
Dataset Kind Image data
Dataset Size 1.3 MB
4D view
SSBD:OMERO
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# 4369
Dataset Kind Image data
Dataset Size 1.2 MB
4D view
SSBD:OMERO
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# 4370
Dataset Kind Image data
Dataset Size 1.5 MB
4D view
SSBD:OMERO
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# 4371
Dataset Kind Image data
Dataset Size 426.5 KB
4D view
SSBD:OMERO
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# 4372
Dataset Kind Image data
Dataset Size 402.5 KB
4D view
SSBD:OMERO
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# 4373
Dataset Kind Image data
Dataset Size 877.5 KB
4D view
SSBD:OMERO
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# 4374
Dataset Kind Image data
Dataset Size 912.9 KB
4D view
SSBD:OMERO
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# 4375
Dataset Kind Image data
Dataset Size 1006.8 KB
4D view
SSBD:OMERO
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# 4376
Dataset Kind Image data
Dataset Size 1.1 MB
4D view
SSBD:OMERO
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# 4377
Dataset Kind Image data
Dataset Size 4.1 MB
4D view
SSBD:OMERO
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# 4378
Dataset Kind Image data
Dataset Size 5.5 MB
4D view
SSBD:OMERO
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# 4379
Dataset Kind Image data
Dataset Size 1.7 MB
4D view
SSBD:OMERO
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# 4380
Dataset Kind Image data
Dataset Size 2.2 MB
4D view
SSBD:OMERO
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# 4381
Dataset Kind Image data
Dataset Size 2.6 MB
4D view
SSBD:OMERO
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# 4382
Dataset Kind Image data
Dataset Size 2.6 MB
4D view
SSBD:OMERO
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# 4383
Dataset Kind Image data
Dataset Size 350.8 KB
4D view
SSBD:OMERO
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# 4384
Dataset Kind Image data
Dataset Size 356.0 KB
4D view
SSBD:OMERO
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# 4385
Dataset Kind Image data
Dataset Size 840.9 KB
4D view
SSBD:OMERO
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# 4386
Dataset Kind Image data
Dataset Size 238.3 KB
4D view
SSBD:OMERO
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# 4387
Dataset Kind Image data
Dataset Size 682.8 KB
4D view
SSBD:OMERO
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# 4388
Dataset Kind Image data
Dataset Size 818.7 KB
4D view
SSBD:OMERO
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# 4389
Dataset Kind Image data
Dataset Size 1.8 MB
4D view
SSBD:OMERO
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# 4390
Dataset Kind Image data
Dataset Size 580.5 KB
4D view
SSBD:OMERO
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Download Image data